Single‐Component‐Based White Light Photoluminescence Emission via Selective Photooxidation in an Organic–Polymer Hybrid System
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201703509
Abstract: White light-emitting phenothiazine-poly(dimethylsiloxane) (PTZ–PDMS) composites are formed by a photooxidation reaction. The oxidized PTZ species, i.e., PTZ cation radicals and dication species, are created by electron transfer from the PTZ molecules to PDMS under UV… read more here.
Keywords: ptz; component based; single component; photooxidation ... See more keywords
The protective effect of vitamin U on pentylenetetrazole‐induced brain damage in rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23169
Abstract: Pentylenetetrazole (PTZ) is preferred for experimental epilepsy induction. PTZ damages brain and other organs by elevating oxidative substances. Vitamin U (Vit U) is sulfur derivative substance that proved to be an excellent antioxidant. The current… read more here.
Keywords: brain damage; ptz; vit; brain ... See more keywords
Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-022-19251-6
Abstract: Epilepsy is one of the most common serious brain disorders, affecting about 1% of the population all over the world. Ginkgo biloba extract (GbE) and L-carnitine (LC) reportedly possess the antioxidative activity and neuroprotective potential.… read more here.
Keywords: ptz; epilepsy; ginkgo biloba; carnitine ... See more keywords
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug
Sign Up to like & getrecommendations! Published in 2019 at "Neurotherapeutics"
DOI: 10.1007/s13311-019-00773-w
Abstract: In our recent studies, we identified compound N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) as a broad-spectrum hybrid anticonvulsant which showed potent protection across the most important animal acute seizure models such as the maximal electroshock (MES) test, the subcutaneous… read more here.
Keywords: dioxopyrrolidin propanamide; benzyl dioxopyrrolidin; ptz; test ... See more keywords
Eugenol induces body immobilization yet evoking an increased neuronal excitability in fish during short-term baths.
Sign Up to like & getrecommendations! Published in 2020 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2020.105734
Abstract: Several studies have suggested eugenol as a suitable anaesthetic for fish. However, it has also been regarded as a toxic and aversive substance to several aquatic organisms, including fish. This study sought to assess the… read more here.
Keywords: eugenol; neuronal excitability; ptz; body immobilization ... See more keywords
Corrole-phenothiazine and porphyrin-phenothiazine dyads connected at β-position: Synthesis and photophysical properties
Sign Up to like & getrecommendations! Published in 2017 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2017.04.062
Abstract: Abstract Two novel donor-acceptor dyads, in which phenothiazine (PTZ) connected at β-pyrrolic position of either freebase corrole (TPC) or freebase porphyrin (TPP) via vinylic spacer have been synthesized. Both the dyads were characterized by ESI-MS,… read more here.
Keywords: ptz dyad; position; ptz; porphyrin ... See more keywords
Discovery of novel Methylsulfonyl phenyl derivatives as potent human Cyclooxygenase-2 inhibitors with effective anticonvulsant action: Design, synthesis, in-silico, in-vitro and in-vivo evaluation.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.04.007
Abstract: A novel series of methylsulfonyl phenyl derivatives has been designed and synthesized to evaluate their COX-2 inhibitory activity along with anti-convulsant potential. In-vitro evaluation revealed that two compounds MTL-1 and MTL-2 appeared as most potent… read more here.
Keywords: ptz; mtl; phenyl derivatives; cox ... See more keywords
Enantiomeric N-substituted phthalimides with excitatory amino acids protect zebrafish larvae against PTZ-induced seizures.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173489
Abstract: Epilepsy is a chronic neurological disease with high prevalence and adverse impacts on the quality of life of patients and caregivers. Up to one-third of individuals with epilepsy do not respond to current pharmacotherapy, underscoring… read more here.
Keywords: zebrafish larvae; amino acids; substituted phthalimides; ptz ... See more keywords
Optimization of a locomotion-based zebrafish seizure model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2022.109594
Abstract: BACKGROUND Locomotor assays in zebrafish have emerged as a screening test in early drug discovery for antiseizure compounds. However, parameters differ considerably between published studies, which may explain some discrepant results with (candidate) antiseizure medications.… read more here.
Keywords: ptz; ptz induced; seizure model; locomotion ... See more keywords
Design and synthesis of phenothiazine based imidazolium ionic liquid for electrochemical nonenzymatic detection of sulfite in food samples
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2019.112412
Abstract: Abstract Herein, we introduce a novel redox mediator based ionic liquid for selective and sensitive detection of sulfite, which is one of the challenging areas of research in food quality control and environmental safety. A… read more here.
Keywords: phenothiazine; ionic liquid; detection; detection sulfite ... See more keywords
Galangin Prevents Increased Susceptibility to Pentylenetetrazol-Stimulated Seizures by Prostaglandin E2
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.06.002
Abstract: Epilepsy is one of the most common chronic neurological diseases. It is characterized by recurrent epileptic seizures, where one-third of patients are refractory to existing treatments. Evidence revealed the association between neuroinflammation and increased susceptibility… read more here.
Keywords: susceptibility pentylenetetrazol; susceptibility; pge2; ptz ... See more keywords