Optimization of a locomotion-based zebrafish seizure model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2022.109594
Abstract: BACKGROUND Locomotor assays in zebrafish have emerged as a screening test in early drug discovery for antiseizure compounds. However, parameters differ considerably between published studies, which may explain some discrepant results with (candidate) antiseizure medications.… read more here.
Keywords: ptz; ptz induced; seizure model; locomotion ... See more keywords
Effects of prednisolone on behavioral and inflammatory profile in animal model of PTZ-induced seizure.
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience letters"
DOI: 10.1016/j.neulet.2020.135560
Abstract: Epilepsy is a chronic neurological condition that affects 1%-2% of the world population. Although research about the disease is advancing and a wide variety of drugs is available, about 30 % of patients have refractory… read more here.
Keywords: animal model; model; prednisolone; ptz induced ... See more keywords
The possible role of nitric oxide signaling and NMDA receptors in allopurinol effect on maximal electroshock- and pentylenetetrazol-induced seizures in mice
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136620
Abstract: Allopurinol, a uric-acid-lowering medication, has shown its efficacy in several studies suggesting that allopurinol can be prescribed as adjunctive cure meant for intractable epilepsy. The exact mechanism of allopurinol is still unknown. This study evaluates… read more here.
Keywords: allopurinol; ptz induced; seizure; effect ... See more keywords
Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the Nrf2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/9966663
Abstract: Epilepsy is a neurodegenerative brain disorder characterized by recurrent seizure attacks. Numerous studies have suggested a strong correlation between oxidative stress and neuroinflammation in several neurodegenerative disorders including epilepsy. This study is aimed at investigating… read more here.
Keywords: carveol; neuroinflammation; ptz induced; carveol attenuates ... See more keywords
New pyrazolone derivatives, synthesis, characterization, and neuroprotective effect against PTZ- induced neuroinflammation in mice
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.62869.13912
Abstract: Objective(s): The study was aimed at synthesis of the new derivatives of the pyrazolone nucleus, and their spectroscopic and pharmacological analysis and evaluation. Materials and Methods: Three series of compounds, with 2-picolinic acid (I a-d),… read more here.
Keywords: picolinic acid; effect; ptz induced; analysis ... See more keywords
In vivo electrophysiological study of vitamin D3 protective effects on PTZ-induced seizures in rats
Sign Up to like & getrecommendations! Published in 2022 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.363596
Abstract: Background and purpose: The purpose of the current study was to investigate the protective effects of acute and chronic administration of different doses of vitamin D3 on pentylenetetrazol (PTZ)-induced epileptiform activities in rats. Experimental approach:… read more here.
Keywords: protective effects; administration; acute; vitamin protective ... See more keywords