Brain targeted lactoferrin coated lipid nanocapsules for the combined effects of apocynin and lavender essential oil in PTZ induced seizures
Sign Up to like & getrecommendations! Published in 2024 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-024-01610-0
Abstract: Apocynin (APO) is a plant derived antioxidant exerting specific NADPH oxidase inhibitory action substantiating its neuroprotective effects in various CNS disorders, including epilepsy. Due to rapid elimination and poor bioavailability, treatment with APO is challenging.… read more here.
Keywords: brain; induced seizures; apo; ptz induced ... See more keywords
Optimization of a locomotion-based zebrafish seizure model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2022.109594
Abstract: BACKGROUND Locomotor assays in zebrafish have emerged as a screening test in early drug discovery for antiseizure compounds. However, parameters differ considerably between published studies, which may explain some discrepant results with (candidate) antiseizure medications.… read more here.
Keywords: ptz; ptz induced; seizure model; locomotion ... See more keywords
Effects of prednisolone on behavioral and inflammatory profile in animal model of PTZ-induced seizure.
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience letters"
DOI: 10.1016/j.neulet.2020.135560
Abstract: Epilepsy is a chronic neurological condition that affects 1%-2% of the world population. Although research about the disease is advancing and a wide variety of drugs is available, about 30 % of patients have refractory… read more here.
Keywords: animal model; model; prednisolone; ptz induced ... See more keywords
The possible role of nitric oxide signaling and NMDA receptors in allopurinol effect on maximal electroshock- and pentylenetetrazol-induced seizures in mice
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136620
Abstract: Allopurinol, a uric-acid-lowering medication, has shown its efficacy in several studies suggesting that allopurinol can be prescribed as adjunctive cure meant for intractable epilepsy. The exact mechanism of allopurinol is still unknown. This study evaluates… read more here.
Keywords: allopurinol; ptz induced; seizure; effect ... See more keywords
Effect of Kruppel‐like factor 4 on PTZ‐induced acute seizure mice
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.18578
Abstract: Kruppel‐like factor 4 (Klf4) is a transcription factor that is involved in neuronal regeneration and the development of glutamatergic systems. However, it is unknown whether Klf4 is involved in acute seizure. To investigate the potential… read more here.
Keywords: complement component; seizure; klf4; ptz ... See more keywords
Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the Nrf2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/9966663
Abstract: Epilepsy is a neurodegenerative brain disorder characterized by recurrent seizure attacks. Numerous studies have suggested a strong correlation between oxidative stress and neuroinflammation in several neurodegenerative disorders including epilepsy. This study is aimed at investigating… read more here.
Keywords: carveol; neuroinflammation; ptz induced; carveol attenuates ... See more keywords
New pyrazolone derivatives, synthesis, characterization, and neuroprotective effect against PTZ- induced neuroinflammation in mice
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.62869.13912
Abstract: Objective(s): The study was aimed at synthesis of the new derivatives of the pyrazolone nucleus, and their spectroscopic and pharmacological analysis and evaluation. Materials and Methods: Three series of compounds, with 2-picolinic acid (I a-d),… read more here.
Keywords: picolinic acid; effect; ptz induced; analysis ... See more keywords
Cannabidiol potentiates phenobarbital effects in the control of pentylenetetrazole (PTZ)-induced epileptic seizures in neonate rats
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2025.1673345
Abstract: Epilepsy is characterized by the predisposition to epileptic seizures resulting from neuronal hyperexcitability and hypersynchrony. Seizure management consists primarily of the long-term use of antiseizure drugs, such as phenobarbital (PB). However, many patients, especially neonates,… read more here.
Keywords: pentylenetetrazole ptz; cbd; 100 200; ptz induced ... See more keywords
Chrysophanol attenuates cognitive impairment, neuroinflammation, and oxidative stress by TLR4/NFκB-Nrf2/HO-1 and BDNF/VEGF signaling in stress-intensified PTZ induced epilepsy in mice
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1446304
Abstract: Background Stress is among the most common comorbid conditions with epilepsy and a strong factor in the pathophysiology of seizures. An imbalance in neuronal circuits causes recurrent unprovoked seizures in epilepsy. Dysregulation of BDNF/VEGF expression,… read more here.
Keywords: bdnf vegf; induced epilepsy; stress; chrysophanol ... See more keywords
In vivo electrophysiological study of vitamin D3 protective effects on PTZ-induced seizures in rats
Sign Up to like & getrecommendations! Published in 2022 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.363596
Abstract: Background and purpose: The purpose of the current study was to investigate the protective effects of acute and chronic administration of different doses of vitamin D3 on pentylenetetrazol (PTZ)-induced epileptiform activities in rats. Experimental approach:… read more here.
Keywords: protective effects; administration; acute; vitamin protective ... See more keywords