The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-017-0627-9
Abstract: Puberty is a major developmental stage. Damaging mutations, considered as “mistakes of nature”, have contributed to the unraveling of the networks implicated in the normal initiation of puberty. Genes involved in the abnormal hypothalamic–pituitary–gonadal (HPG)… read more here.
Keywords: precocious puberty; genetics; puberty initiation; gnrh ... See more keywords
Evolutionary Conservation of MKRN3 and Other Makorins and Their Roles in Puberty Initiation and Endocrine Functions.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in reproductive medicine"
DOI: 10.1055/s-0039-3400965
Abstract: Puberty is a critical period of development regulated by genetic, nutritional, and environmental factors. The role of makorin ring finger protein 3 (MKRN3) in the regulation of pubertal timing was revealed when loss-of-function mutations were… read more here.
Keywords: mkrn3; endocrine functions; initiation endocrine; evolutionary conservation ... See more keywords
Mkrn3 functions as a novel ubiquitin E3 ligase to inhibit Nptx1 during puberty initiation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19347
Abstract: Central precocious puberty (CPP) is attributed to the disorder of some trigger factors those can activate the hypothalamic-pituitary-gonadal axis controlled by GnRH neurons. Many recent studies reveal one of those trigger factors, Makorin ring finger… read more here.
Keywords: puberty initiation; ubiquitin ligase; puberty; mkrn3 ... See more keywords
Molecular and Environmental Mechanisms Regulating Puberty Initiation: An Integrated Approach
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00828
Abstract: The mechanisms underlying the initiation of puberty, one of the cornerstones of human evolution, have not been fully elucidated as yet. However, recently, an accumulating body of evidence has helped unravel several critical aspects of… read more here.
Keywords: initiation; mechanisms regulating; environmental mechanisms; molecular environmental ... See more keywords