Inflated expectations: Rare-variant association analysis using public controls
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DOI: 10.1371/journal.pone.0280951
Abstract: The use of publicly available sequencing datasets as controls (hereafter, “public controls”) in studies of rare variant disease associations has great promise but can increase the risk of false-positive discovery. The specific factors that could… read more here.
Keywords: positive discovery; public controls; variant association; rare variant ... See more keywords