Puerarin Protects Against LPS-Induced Vascular Endothelial Cell Hyperpermeability via Preventing Downregulation of Endothelial Cadherin
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01014-0
Abstract: In the present study, we aimed to investigate the effects of puerarin on the hyperpermeability of vascular endothelial cells induced by lipopolysaccharide (LPS) and its underlying mechanisms. Human umbilical vein endothelial cells (HUVECs) were pre-incubated… read more here.
Keywords: lps induced; puerarin; hyperpermeability; vascular endothelial ... See more keywords
Puerarin Up-regulates Methyl-CpG Binding Protein 2 Phosphorylation in Hippocampus of Vascular Dementia Rats
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-018-2822-0
Abstract: ObjectiveTo observe the effect of puerarin on methyl-CpG binding protein 2 (MeCP2) phosphorylation (pMeCP2) in the hippocampus of a rat model of vascular dementia (VD).MethodsThirty-six healthy Sprague-Dawley rats were randomly assigned to the sham-operated group,… read more here.
Keywords: sham operated; hippocampus; puerarin; dementia ... See more keywords
FGF-2 signaling activation in the hippocampus contributes to the behavioral and cellular responses to puerarin.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.06.025
Abstract: Puerarin, a well-studied isoflavone isolated from Pueraria lobata, produces an antidepressant-like effect. Fibroblast growth factor-2 (FGF-2) is essentially required in the central nervous system as it acts as both a neurotrophic or anti-inflammatory regulator for… read more here.
Keywords: fgf; hippocampus; puerarin; like effect ... See more keywords
Continuous separation of puerarin from Pueraria crude extract by fractional Extraction: Simulation and optimization
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Science"
DOI: 10.1016/j.ces.2021.116671
Abstract: Abstract Fractional extraction was conducted to accurately separate puerarin from the crude Pueraria extract. Two green, efficient extraction systems of pure solvents were explored for the successive purification of puerarin by fractional extraction. The extraction… read more here.
Keywords: fractional extraction; simulation optimization; extraction; puerarin ... See more keywords
Investigating the solid-liquid extraction process of puerarin by molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Heat and Mass Transfer"
DOI: 10.1016/j.ijheatmasstransfer.2019.118584
Abstract: Abstract The solid-liquid extraction is an efficient method to obtain bioactive components from natural medicinal herbs. The diffusion of the bioactive molecule is the key to efficient solid-liquid extraction. The current research aims to investigate… read more here.
Keywords: solid liquid; puerarin; extraction; extraction process ... See more keywords
Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.120002
Abstract: Human activities in the areas of high altitude have increased significantly recently. Brain is highly sensitive to changing of oxygen pressure due to high altitude, and this physiological response may lead to serious brain injury,… read more here.
Keywords: puerarin tisgs; brain; brain injury; puerarin ... See more keywords
Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Translation"
DOI: 10.1016/j.jot.2022.01.003
Abstract: Objective Given the limitations of current anti-resorption agents for postmenopausal osteoporosis, there is a need for alternatives without impairing coupling crosstalk between bone resorption and bone formation ie. osteoclastogenesis. Puerarin, a unique C-glycoside isoflavonoid, was… read more here.
Keywords: bone; activation; osteoclast activation; bone resorption ... See more keywords
Sensitive and selective detection of puerarin based on the hybrid of reduced graphene oxide and molecularly imprinted polymer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113221
Abstract: Puerarin, an important isoflavone, has been widely used for the treatment of angina and hypertension. In this work, we developed a novel electrochemical sensor for the detection of puerarin based on the hybrid of reduced… read more here.
Keywords: detection; puerarin; microscopy; puerarin based ... See more keywords
Therapeutic potential of puerarin against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis determined by combination of 1H NMR spectroscopy-based metabonomics and 16S rRNA gene sequencing.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.113964
Abstract: Previously published studies have revealed the protective effect of puerarin against non-alcoholic steatohepatitis (NASH), but the definite mechanism of this effect still remains unclear. The present work was an attempt to assess the beneficial effects… read more here.
Keywords: puerarin; 16s rrna; rrna gene; spectroscopy ... See more keywords
Oral Delivery of Puerarin Nanocrystals To Improve Brain Accumulation and Anti-Parkinsonian Efficacy.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b01012
Abstract: Puerarin (PU) has emerged as a promising herb-derived anti-Parkinsonism compound. However, the undesirable water solubility as well as the unwanted bioavailability of PU limit its application. Therefore, this study aimed to develop and characterize PU… read more here.
Keywords: oral delivery; brain accumulation; brain; puerarin ... See more keywords
Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0401-y
Abstract: Estrogen deficiency induces cardiac dysfunction and increases the risk of cardiovascular disease in postmenopausal women and in those who underwent bilateral oophorectomy. Previous evidence suggests that puerarin, a phytoestrogen, exerts beneficial effects on cardiac function… read more here.
Keywords: cardiac hypertrophy; puerarin; pgc pathway; hypertrophy ... See more keywords