Change of right ventricular systolic pressure can indicate dasatinib‐induced pulmonary arterial hypertension in chronic myeloid leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3588
Abstract: We investigated the feasibility of the clinical application of non‐invasive transthoracic echocardiography for diagnosis of pulmonary arterial hypertension induced by dasatinib (D‐PAH) in chronic myeloid leukemia (CML). read more here.
Keywords: pulmonary arterial; myeloid leukemia; arterial hypertension; chronic myeloid ... See more keywords
Impact of different sequential triple oral combination therapies based selexipag on outcomes in pulmonary arterial hypertension
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DOI: 10.1002/clc.24245
Abstract: While the GRIPHON study and others have confirmed the efficacy and safety of selexipag with single, dual, and initial triple combination therapy for patients with pulmonary arterial hypertension (PAH), multicenters studies concerning diverse triple oral… read more here.
Keywords: oral combination; combination; triple oral; arterial hypertension ... See more keywords
Population Pharmacokinetic/Pharmacodynamic and Exposure‐Response Modeling Analyses of Sotatercept in Healthy Participants and Patients with Pulmonary Arterial Hypertension
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3524
Abstract: Sotatercept is a breakthrough, first‐in‐class biologic, recently approved by the Food and Drug Administration (FDA) for the treatment of pulmonary arterial hypertension (PAH). Exposure‐response (E‐R) analyses and pharmacokinetic/pharmacodynamic (PK/PD) modeling were performed for sotatercept after… read more here.
Keywords: arterial hypertension; pharmacokinetic pharmacodynamic; exposure response; pulmonary arterial ... See more keywords
An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.478
Abstract: Pulmonary arterial hypertension (PAH) is an often fatal condition, the primary pathology of which involves loss of pulmonary vascular perfusion due to progressive aberrant vessel remodeling. The reduced capacity of the pulmonary circulation places increasing… read more here.
Keywords: bmp signaling; arterial hypertension; bmp; pulmonary arterial ... See more keywords
Critical appraisal of the instantaneous end‐diastolic pulmonary arterial wedge pressures
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DOI: 10.1002/ehf2.13057
Abstract: A substantial shift in the field of pulmonary hypertension (PH) is ongoing, as the previous practice of mean pulmonary arterial wedge pressure (PAWPM) is no longer supported. Instead, aiming for a better estimate of end‐diastolic… read more here.
Keywords: pulmonary arterial; arterial wedge; end diastolic;
Does pulmonary artery pulsatility index predict mortality in pulmonary arterial hypertension?
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DOI: 10.1002/ehf2.13450
Abstract: Pulmonary artery pulsatility index (PAPi), defined as [(pulmonary artery systolic pressure − diastolic pulmonary artery pressure)/mean right atrial pressure], is a novel haemodynamic index that predicts right ventricular failure after myocardial infarction and left ventricular… read more here.
Keywords: artery; artery pulsatility; pulmonary arterial; pulmonary artery ... See more keywords
Renal replacement therapy as a therapeutic option for right heart failure in severe pulmonary arterial hypertension.
Sign Up to like & getrecommendations! Published in 2022 at "ESC heart failure"
DOI: 10.1002/ehf2.13945
Abstract: Pulmonary arterial hypertension (PAH) is a progressively life-threatening disease that causes right heart failure (RHF). Renal dysfunction frequently complicates PAH with RHF and is associated with a worse prognosis. Renal replacement therapy (RRT) may be… read more here.
Keywords: pah; arterial hypertension; pulmonary arterial; heart failure ... See more keywords
Optimal combination of right ventricular functional parameters using echocardiography in pulmonary arterial hypertension
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DOI: 10.1002/ehf2.14752
Abstract: Novel echocardiographic parameters of right ventricular (RV) function, including speckle‐tracking‐derived, three‐dimensional, and RV–pulmonary artery coupling parameters, have emerged for the evaluation of pulmonary arterial hypertension (PAH). The relative role of these parameters in the risk… read more here.
Keywords: arterial hypertension; right ventricular; pulmonary arterial; optimal combination ... See more keywords
Phenotype and outcomes according to loop diuretic use in pulmonary arterial hypertension
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DOI: 10.1002/ehf2.14818
Abstract: The use of loop diuretics in pulmonary arterial hypertension (PAH) is less frequent compared with heart failure. The clinical and prognostic characteristics of PAH patients according to loop diuretic use remain unexplored. In this study,… read more here.
Keywords: use; arterial hypertension; loop diuretic; diuretic use ... See more keywords
Pulmonary congestion in patients with pulmonary arterial hypertension? New insights from lung ultrasound
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DOI: 10.1002/ejhf.3259
Abstract: . Pulmonary congestion (or oedema) is a key feature of the heart failure (HF) syndrome and associated with dyspnoea, a decrease in exercise tolerance read more here.
Keywords: congestion; patients pulmonary; arterial hypertension; congestion patients ... See more keywords
Circulating plasmablasts are elevated and produce pathogenic anti‐endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747460
Abstract: Idiopathic pulmonary arterial hypertension (IPAH) is a devastating pulmonary vascular disease in which autoimmune and inflammatory phenomena are implicated. B cells and autoantibodies have been associated with IPAH and identified as potential therapeutic targets. However,… read more here.
Keywords: idiopathic pulmonary; arterial hypertension; endothelial cell; pulmonary arterial ... See more keywords