A comprehensive screening platform for aerosolizable protein formulations for intranasal and pulmonary drug delivery.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.027
Abstract: Aerosolized administration of biopharmaceuticals to the airways is a promising route for nasal and pulmonary drug delivery, but - in contrast to small molecules - little is known about the effects of aerosolization on safety… read more here.
Keywords: aerosolization; drug delivery; delivery; platform ... See more keywords
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2137143
Abstract: ABSTRACT Introduction Drugs for the treatment of respiratory diseases are commonly administered by oral inhalation. Yet surprisingly little is known about the pulmonary pharmacokinetics of inhaled molecules. Nuclear medicine imaging techniques (i.e. planar gamma scintigraphy,… read more here.
Keywords: medicine imaging; pulmonary drug; nuclear medicine; imaging techniques ... See more keywords
Fundamentals and Applications of Isolated Perfused Lung (IPL) Model in the Development of Pulmonary Drug Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug delivery"
DOI: 10.2174/1567201819666220823161318
Abstract: Estimating parameters such as pulmonary drug disposition and deposited dose, as well as determining the influence of pulmonary pharmacokinetics (PK) on drug efficacy and safety, are critical factors for the development of inhaled drug products… read more here.
Keywords: ipl model; pulmonary drug; lung; model ... See more keywords
Polyhydroxyalkanoate Nanoparticles for Pulmonary Drug Delivery: Interaction with Lung Surfactant
Sign Up to like & getrecommendations! Published in 2021 at "Nanomaterials"
DOI: 10.3390/nano11061482
Abstract: Polyhydroxyalkanoates (PHA) are polyesters produced intracellularly by many bacterial species as energy storage materials, which are used in biomedical applications, including drug delivery systems, due to their biocompatibility and biodegradability. In this study, we evaluated… read more here.
Keywords: drug delivery; drug; polyhydroxyalkanoate nanoparticles; interaction ... See more keywords
Advances in Pulmonary Drug Delivery
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12100911
Abstract: Pulmonary drug delivery represents an attractive, non-invasive administration option. In addition to locally acting drugs, molecules that are intended to produce systemic effects can be delivered via the pulmonary route. Several factors need to be… read more here.
Keywords: drug delivery; formulation; drug; advances pulmonary ... See more keywords