Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS‐CoV‐2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12071
Abstract: Abstract The pathobiology of in situ pulmonary thrombosis in acute respiratory distress syndrome (ARDS) due to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection is incompletely characterized. In human pulmonary artery endothelial cells (HPAECs), hypoxia increases… read more here.
Keywords: cov ards; syndrome; acute respiratory; pulmonary endothelial ... See more keywords
Pulmonary endothelial chimerism after hematopoietic stem cell transplantation
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DOI: 10.1007/s00595-017-1562-2
Abstract: PurposeFew studies have investigated pulmonary endothelial chimerism after hematopoietic stem cell transplantation. In the present study, we investigated pulmonary endothelial chimerism using the ABH histo-blood group antigen as an identifying marker in cases of ABO-incompatible… read more here.
Keywords: endothelial chimerism; cell transplantation; stem cell; pulmonary endothelial ... See more keywords
Endocytosis of Red Blood Cell Microparticles by Pulmonary Endothelial Cells is Mediated By Rab5
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DOI: 10.1097/shk.0000000000000995
Abstract: ABSTRACT Microparticles are submicron vesicles shed from aging erythrocytes as a characteristic feature of the red blood cell (RBC) storage lesion. Exposure of pulmonary endothelial cells to RBC-derived microparticles promotes an inflammatory response, but the… read more here.
Keywords: red blood; endocytosis; pulmonary endothelial; blood cell ... See more keywords
Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration
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DOI: 10.1101/2022.10.14.512212
Abstract: Following acute injury, the capillary vascular bed in the lung must be repaired to reestablish gas exchange with the external environment. Little is known about the transcriptional and signaling factors that drive pulmonary endothelial cell… read more here.
Keywords: regeneration; pulmonary endothelial; lung; atf3 ... See more keywords
Adipose-Derived Circulating Exosomes Promote Protection of the Pulmonary Endothelial Barrier by Inhibiting EndMT and Oxidative Stress through Down-Regulation of the TGF-β Pathway: A Potential Explanation for the Obesity Paradox in ARDS
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DOI: 10.1155/2022/5475832
Abstract: The “obesity paradox in acute respiratory distress syndrome” (ARDS) refers to the phenomenon in which obesity is associated with higher morbidity but lower mortality in patients with ARDS. Endothelial-to-mesenchymal transition (EndMT) represents a key link… read more here.
Keywords: endothelial barrier; obesity paradox; adipose derived; endmt oxidative ... See more keywords
Protectin DX Relieve Hyperoxia‐induced Lung Injury by Protecting Pulmonary Endothelial Glycocalyx
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DOI: 10.2147/jir.s391765
Abstract: Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants with limited treatments and poor prognosis. Damaged endothelial glycocalyx leads to vascular permeability, lung edema and inflammation. However, whether hyperoxia increases neonatal… read more here.
Keywords: hyperoxia induced; pulmonary endothelial; lung; glycocalyx ... See more keywords
PIEZO1 Ion Channel Mediates Ionizing Radiation-Induced Pulmonary Endothelial Cell Ferroptosis via Ca2+/Calpain/VE-Cadherin Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.725274
Abstract: Pulmonary endothelial cell dysfunction plays an important role in ionizing radiation (IR)-induced lung injury. Whether pulmonary endothelial cell ferroptosis occurs after IR and what are the underlying mechanisms remain elusive. Here, we demonstrate that 15-Gy… read more here.
Keywords: ferroptosis; radiation induced; pulmonary endothelial; endothelial cell ... See more keywords
Direct Thrombin Inhibitor Dabigatran Compromises Pulmonary Endothelial Integrity in a Murine Model of Breast Cancer Metastasis to the Lungs; the Role of Platelets and Inflammation-Associated Haemostasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.834472
Abstract: Activation of the coagulation cascade favours metastatic spread, but antithrombotic therapy might also have detrimental effects on cancer progression. In this study, we characterized the effects of dabigatran, a direct reversible thrombin inhibitor, on the… read more here.
Keywords: cancer; breast cancer; metastasis; model ... See more keywords
Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.53072
Abstract: Pulmonary endothelial cells (ECs) are an essential component of the gas exchange machinery of the lung alveolus. Despite this, the extent and function of lung EC heterogeneity remains incompletely understood. Using single-cell analytics, we identify… read more here.
Keywords: lung; pulmonary endothelial; acute lung; lung injury ... See more keywords