Effects of CFTR modulators on pharmacokinetics of tobramycin during acute pulmonary exacerbations in the pediatric cystic fibrosis population
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DOI: 10.1002/ppul.24917
Abstract: Individuals with cystic fibrosis (CF) require higher dosages of aminoglycosides due to an increased volume of distribution (Vd) and clearance. Optimal dosing of aminoglycosides in the CF population is essential as repeated exposure to aminoglycosides… read more here.
Keywords: cystic fibrosis; effects cftr; fibrosis; pulmonary exacerbations ... See more keywords
State of the art in cystic fibrosis pharmacology optimization of antimicrobials in the treatment of cystic fibrosis pulmonary exacerbations: III. Executive summary
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DOI: 10.1002/ppul.25353
Abstract: Acute pulmonary exacerbations are complications of cystic fibrosis (CF) and are associated with increased morbidity and mortality. Methicillin‐resistant Staphylococcus aureus (MRSA) and Aspergillus fumigatus are organisms that have been detected in the lungs of CF… read more here.
Keywords: cystic fibrosis; art cystic; pharmacology; pulmonary exacerbations ... See more keywords
Aminoglycoside dosing and monitoring for Pseudomonas aeruginosa during acute pulmonary exacerbations in cystic fibrosis.
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DOI: 10.1002/ppul.25441
Abstract: Aminoglycosides are commonly used for the treatment of Pseudomonas aeruginosa (PsA) in the setting of acute pulmonary exacerbations (PEx) in pediatric patients with cystic fibrosis (CF). There are controversies and practice differences between institutions related… read more here.
Keywords: cystic fibrosis; pseudomonas aeruginosa; aminoglycoside dosing; dosing monitoring ... See more keywords
Optimization of antibiotics for cystic fibrosis pulmonary exacerbations due to highly resistant nonlactose fermenting Gram negative bacilli: Meropenem‐vaborbactam and cefiderocol
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DOI: 10.1002/ppul.25552
Abstract: We are writing this letter to provide an update of published information on antibiotics for cystic fibrosis (CF) pulmonary exacerbations to the State of the Art articles by Zobell et al. Information on meropenem‐vaborbactam and… read more here.
Keywords: cystic fibrosis; meropenem vaborbactam; pulmonary exacerbations; vaborbactam cefiderocol ... See more keywords
Pulmonary exacerbations, airway pathogens, and long‐term course of lung clearance index in children and young adults with cystic fibrosis
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DOI: 10.1002/ppul.26136
Abstract: Pulmonary exacerbations (PEx), pathogens colonizing the respiratory tract, and patients' age are associated with progressive worsening of lung function among patients with cystic fibrosis (CF). However, the effect of these factors on longitudinal changes of… read more here.
Keywords: cystic fibrosis; lung clearance; clearance index; pulmonary exacerbations ... See more keywords
Impact of viral respiratory infections on pulmonary exacerbations in children with cystic fibrosis
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DOI: 10.1002/ppul.26267
Abstract: Viral respiratory infections trigger pulmonary exacerbations (PEs) in children with cystic fibrosis (CF), but their clinical impact is not well understood. read more here.
Keywords: viral respiratory; respiratory infections; pulmonary exacerbations; children cystic ... See more keywords
Early Detection of Cystic Fibrosis Acute Pulmonary Exacerbations by Exhaled Breath Condensate Metabolomics.
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DOI: 10.1021/acs.jproteome.9b00443
Abstract: The most common cause of death in cystic fibrosis (CF) patients is progressive lung function decline, which is punctuated by acute pulmonary exacerbations (APEs). A major challenge is to discover biomarkers for detecting an oncoming… read more here.
Keywords: cystic fibrosis; exhaled breath; pulmonary exacerbations; ape ... See more keywords
Early detection of pulmonary exacerbations in children with Cystic Fibrosis by electronic home monitoring of symptoms and lung function
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DOI: 10.1038/s41598-017-10945-3
Abstract: Pulmonary exacerbations (PEx) in Cystic Fibrosis (CF) are associated with an increased morbidity and even mortality. We investigated whether early detection of PEx in children with CF is possible by electronic home monitoring of symptoms… read more here.
Keywords: home; cystic fibrosis; fev1 pred; early detection ... See more keywords
Identification of novel blood biomarkers of treatment response in cystic fibrosis pulmonary exacerbations by label-free quantitative proteomics
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DOI: 10.1038/s41598-019-53759-1
Abstract: Pulmonary exacerbations (PEx) are clinically impactful events for individuals with CF. Unfortunately, many CF individuals with PEx fail to regain their baseline lung function despite treatment. The objective of this study was to use unbiased… read more here.
Keywords: response; novel blood; treatment; quantitative proteomics ... See more keywords
Outpatient management of pulmonary exacerbations in children with cystic fibrosis
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DOI: 10.1080/17476348.2023.2202852
Abstract: ABSTRACT Introduction Pulmonary exacerbations are common events in children with cystic fibrosis (CF) and are usually treated with oral antibiotics on an outpatient basis. Even these mild clinical events are clinically meaningful and contribute to… read more here.
Keywords: exacerbations children; pulmonary exacerbations; management; children cystic ... See more keywords
Optimizing outcomes of pulmonary exacerbations in cystic fibrosis
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DOI: 10.1097/mcp.0000000000000519
Abstract: Purpose of review Pulmonary exacerbations are described as worsening of the daily symptoms of cystic fibrosis airways disease, typically with increased cough and sputum production. There are often associated signs such as weight loss and… read more here.
Keywords: cystic fibrosis; treatment; optimizing outcomes; pulmonary exacerbations ... See more keywords