Targeted Dual Small Interfering Ribonucleic Acid Delivery via Non-Viral Polymeric Vectors for Pulmonary Fibrosis Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202007798
Abstract: Inhibiting the myofibroblast differentiation of lung-resident mesenchymal stem cells (LR-MSCs) is a promising yet challenging approach for pulmonary fibrosis (PF) therapy. Here, micelles formed by a graft copolymer of multiple PEGs modified branched polyethylenimine are… read more here.
Keywords: myofibroblast differentiation; fibrosis therapy; small interfering; pulmonary fibrosis ... See more keywords
Inhaled mRNA Nanoformulation with Biogenic Ribosomal Protein Reverses Established Pulmonary Fibrosis in a Bleomycin‐Induced Murine Model
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202107506
Abstract: Idiopathic pulmonary fibrosis (IPF), a lethal respiratory disease with few treatment options, occurs due to repetitive microinjuries to alveolar epithelial cells (AECs) and progresses with an overwhelming deposition of extracellular matrix (ECM), ultimately resulting in… read more here.
Keywords: ribosomal protein; bleomycin induced; pulmonary fibrosis; mrna nanoformulation ... See more keywords
Modulation of CD11c+ lung dendritic cells in respect to TGF‐β in experimental pulmonary fibrosis
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DOI: 10.1002/cbin.10800
Abstract: Idiopathic pulmonary fibrosis (IPF) is a deadly, progressive lung disease with very few treatment options till now. Bleomycin‐induced pulmonary fibrosis (BIPF) is a commonly used mice model in IPF research. TGF‐β1 has been shown to… read more here.
Keywords: cd11c; dcs; tgf; pulmonary fibrosis ... See more keywords
Screening of Inhibitors Targeting Heat Shock Protein 47 Involved in the Development of Idiopathic Pulmonary Fibrosis
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DOI: 10.1002/cmdc.202100064
Abstract: Heat shock protein 47 (HSP47), a collagen‐specific molecular chaperone, is causally related to fibrotic diseases, including idiopathic pulmonary fibrosis. The identification of Compounds that interfere with the HSP47‐collagen interaction is essential for the development of… read more here.
Keywords: protein; idiopathic pulmonary; heat shock; pulmonary fibrosis ... See more keywords
Oxidative Stress in Pulmonary Fibrosis.
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DOI: 10.1002/cphy.c190017
Abstract: Oxidative stress has been linked to various disease states as well as physiological aging. The lungs are uniquely exposed to a highly oxidizing environment and have evolved several mechanisms to attenuate oxidative stress. Idiopathic pulmonary… read more here.
Keywords: stress; biology; pulmonary fibrosis; stress pulmonary ... See more keywords
Atorvastatin attenuates pulmonary fibrosis in mice and human lung fibroblasts, by the regulation of myofibroblast differentiation and apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23074
Abstract: Statins have anti‐inflammatory and antifibrotic effects in addition to cholesterol‐lowering effect. We aimed to investigate the effect of atorvastatin (ATR) in fibrotic mouse lung and human lung fibroblasts (MRC5s). Pulmonary fibrosis was induced by a… read more here.
Keywords: myofibroblast differentiation; apoptosis; pulmonary fibrosis; mice ... See more keywords
Targeting anti‐aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28033
Abstract: Idiopathic pulmonary fibrosis (IPF) is a severe, incurable, age‐associated respiratory disorder that has gained significance because of its unknown etiology and lack of therapeutic approaches. IPF causes maximum damage to the alveolar epithelial cells, thereby… read more here.
Keywords: protein; fibrosis; diagnosis; idiopathic pulmonary ... See more keywords
A nonsynonymous polymorphism (rs117179004, T392M) of hyaluronidase 1 (HYAL1) is associated with increased risk of idiopathic pulmonary fibrosis in Southern Han Chinese
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23782
Abstract: Idiopathic pulmonary fibrosis (IPF) is a genetic heterogeneous disease with high mortality and poor prognosis. Hyaluronidase 1 (HYAL1) was found to be upregulated in fibroblasts from IPF patients, and overexpression of HYAL1 could prevent human… read more here.
Keywords: idiopathic pulmonary; hyaluronidase hyal1; pulmonary fibrosis; hyal1 ... See more keywords
Detection of interstitial pneumonia with autoimmune features and idiopathic pulmonary fibrosis are enhanced by involvement of matrix metalloproteinases levels and clinical diagnosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24734
Abstract: Higher detection of interstitial pneumonia with autoimmune features (IPAF), and idiopathic pulmonary fibrosis (IPF), has significant diagnostic and therapeutic implications. Some matrix metalloproteinases (MMPs) have become reliable diagnostic biomarkers in IPAF and IPF in previous… read more here.
Keywords: detection interstitial; autoimmune features; idiopathic pulmonary; pulmonary fibrosis ... See more keywords
Sirtuin 6 ameliorates bleomycin-induced pulmonary fibrosis via activation of lipid catabolism.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular physiology"
DOI: 10.1002/jcp.31027
Abstract: Pulmonary fibrosis is a chronic and serious interstitial lung disease with little effective therapies currently. Our incomplete understanding of its pathogenesis remains obstacles in therapeutic developments. Sirtuin 6 (SIRT6) has been shown to mitigate multiple… read more here.
Keywords: bleomycin induced; pulmonary fibrosis; sirt6; fibrosis ... See more keywords
Grading Bleomycin‐Induced Pulmonary Fibrosis in ex vivo Mouse Lungs Using Ultrasound Image Analysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.15448
Abstract: The aim of this study was to assess bleomycin‐induced pulmonary fibrosis on ex vivo mouse lungs using ultrasound image grading and texture analysis. read more here.
Keywords: bleomycin induced; fibrosis vivo; mouse lungs; induced pulmonary ... See more keywords