Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21995
Abstract: Viral pneumonia is a common complication caused by Influenza A virus infection and is characterized by severe pulmonary inflammation. A previous study showed that berberine (BBR) significantly ameliorated the pulmonary inflammation in mice with influenza… read more here.
Keywords: pulmonary inflammation; viral pneumonia; activation; nlrp3 inflammasome ... See more keywords
p38 Inhibition Ameliorates Inspiratory Resistive Breathing-Induced Pulmonary Inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0831-6
Abstract: Inspiratory resistive breathing (IRB), a hallmark of obstructive airway diseases, is associated with strenuous contractions of the inspiratory muscles and increased negative intrathoracic pressures that act as an injurious stimulus to the lung. We have… read more here.
Keywords: pulmonary inflammation; inspiratory resistive; induced pulmonary; inflammation ... See more keywords
MicroRNA-382-5p is involved in pulmonary inflammation induced by fine particulate matter exposure.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.114278
Abstract: Exposure to atmospheric particulate matter (PM) has been related to the increasing incidence and mortality of pulmonary diseases, where microRNAs (miRNAs) play significant roles in these biological and pathological processes. In the present study, we… read more here.
Keywords: pulmonary inflammation; mir 382; pm2 deps; exposure ... See more keywords
Cigarette smoke extract combined with LPS down-regulates the expression of MRP2 in chronic pulmonary inflammation may be related to FXR.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.06.019
Abstract: The transporter multidrug resistance protein 2 (MRP2) plays an important role in chronic pulmonary inflammation by transporting cigarette smoke and other related inflammatory mediators. However, it is not completely clear whether pulmonary inflammation caused by… read more here.
Keywords: fxr; pulmonary inflammation; cigarette smoke; inflammation ... See more keywords
Proinflammatory effects of environmental cadmium boost resistance to opportunistic pathogen Aspergillus fumigatus: implications for sustained low-level pulmonary inflammation?
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152634
Abstract: Cadmium (Cd) is one of the most toxic environmental heavy metals to which the general population is exposed mainly via the oral route. Owing to its immunomodulatory potential, orally acquired Cd affects antimicrobial immune defense… read more here.
Keywords: pulmonary inflammation; response; proinflammatory effects; orally acquired ... See more keywords
Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal Immunology"
DOI: 10.1038/mi.2017.3
Abstract: The molecular mechanisms underlying the pathogenesis of chronic obstructive pulmonary disease (COPD) are still unclear, however signaling pathways associated with lung development, such as the transforming growth factor (TGF)-β superfamily, could be implicated in COPD.… read more here.
Keywords: pulmonary inflammation; patients copd; cigarette smoke; inflammation ... See more keywords
Aurintricarboxylic acid mitigates cigarette smoke extract induced oxidative stress and pulmonary inflammation via inhibition of NF-ҡB/p65 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2022.2090302
Abstract: Abstract Cigarette smoke (CS) induced emphysema and chronic pulmonary inflammation are major comorbidities of chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality worldwide. CS exposure exacerbates pulmonary inflammation and compromises immunity… read more here.
Keywords: pulmonary inflammation; cigarette smoke; inflammation; p65 ... See more keywords
Involvement of the cytokine–IDO1–AhR loop in zinc oxide nanoparticle-induced acute pulmonary inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Nanotoxicology"
DOI: 10.1080/17435390.2017.1306129
Abstract: Abstract Zinc oxide nanoparticles (ZnONPs) are widely used in our daily life, such as in sunscreens and electronic nanodevices. However, pulmonary exposure to ZnONPs causes acute pulmonary inflammation, which is considered as an initial event… read more here.
Keywords: pulmonary inflammation; cytokine; zinc; ahr ... See more keywords
Protective role of cortistatin in pulmonary inflammation and fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15615
Abstract: Acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and pulmonary fibrosis remain major causes of morbidity, mortality and a healthcare burden in critically ill patient. There is an urgent need to identify factors causing… read more here.
Keywords: inflammation fibrosis; pulmonary inflammation; fibrosis; cortistatin ... See more keywords
KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.129110
Abstract: Dysregulated proinflammatory cytokine release has been implicated in the pathogenesis of several life-threatening acute lung illnesses such as pneumonia, sepsis, and acute respiratory distress syndrome. Suppressors of cytokine signaling proteins, particularly SOCS2, have recently been… read more here.
Keywords: pulmonary inflammation; kiaa0317; socs2 degradation; inflammation ... See more keywords
Resistive breathing aggravates cigarette smoke-induced pulmonary inflammation
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/1393003.congress-2017.oa4829
Abstract: Introduction: Resistive breathing (RB) is the hallmark of diseases of airway obstruction, such as chronic obstructive pulmonary disease (COPD), especially during exacerbations. RB results in increased mechanical stress and inflammation in the lung of previously… read more here.
Keywords: pulmonary inflammation; cigarette smoke; resistive breathing;