Mechanical signaling in a pulmonary microvascular endothelial cell monolayer.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.169
Abstract: The mechanical microenvironment of an endothelial cell includes a stable protein scaffold on the basal side, flowing blood on the apical side and contractile cells on the lateral sides. Interaction with the protein scaffold and… read more here.
Keywords: monolayer; endothelial cell; microvascular endothelial; mechanical signaling ... See more keywords
LPS induces pulmonary microvascular endothelial cell barrier dysfunction by upregulating ceramide production.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2022.110250
Abstract: The specific role of ceramides in pulmonary microvascular endothelial cell (PMVEC) barrier dysfunction remains unclear. In the present study, pretreatment with pan-caspase inhibitors significantly reduced LPS-induced PMVEC apoptosis and helped to stimulate PMVEC barrier reconstruction… read more here.
Keywords: dysfunction; pulmonary microvascular; apoptosis; barrier dysfunction ... See more keywords
Pravastatin attenuates sepsis-induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of Cav-1/eNOS pathway.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108077
Abstract: BACKGROUND Disruption of alveolar endothelial barrier caused by inflammation drives the progression of septic acute lung injury (ALI). Pravastatin, an inhibitor of HMG Co-A reductase, has potent anti-inflammatory effects. In the present study, we aim… read more here.
Keywords: microvascular permeability; cav enos; pulmonary microvascular; sepsis induced ... See more keywords
Tumor necrosis factor-α requires Ezrin to regulate the cytoskeleton and cause pulmonary microvascular endothelial barrier damage
Sign Up to like & getrecommendations! Published in 2020 at "Microvascular Research"
DOI: 10.1016/j.mvr.2020.104093
Abstract: Acute respiratory distress syndrome (ARDS) is a rapidly progressive disease with unknown pathogenesis. Damage of pulmonary microvascular endothelial cells(PMVECs) caused by inflammatory storm caused by cytokines such as TNF- α is the potential pathogenesis of… read more here.
Keywords: cytoskeleton; barrier; endothelial barrier; microvascular endothelial ... See more keywords
Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/1118195
Abstract: Background Mitochondria have been involved in host defense upon viral infections. Factor Xa (FXa), a coagulating factor, may also have influence on mitochondrial functionalities. The aim was to analyze if in human pulmonary microvascular endothelial… read more here.
Keywords: metabolism; human pulmonary; spike; factor ... See more keywords
PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory cell and molecular biology"
DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2021
Abstract: Pulmonary microvascular endothelial cells contribute to integrity of the lung gas exchange interface and they are highly glycolytic. While glucose and fructose represent discrete substrates available for glycolysis, pulmonary microvascular endothelial cells prefer glucose over… read more here.
Keywords: endothelial cells; pfkfb3 inhibits; pfkfb3 knockout; inhibits fructose ... See more keywords
ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF-κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-022-00565-7
Abstract: Background Inflammation plays a major role in the pulmonary artery hypertension (PAH) and the acute lung injury (ALI) diseases. The common feature of these complications is the dysfunction of pulmonary microvascular endothelial cells (PMVECs). Fasudil,… read more here.
Keywords: rat; pulmonary microvascular; rock inhibitor; endothelial cells ... See more keywords
PECAM EMPs regulate apoptosis in pulmonary microvascular endothelial cells in COPD by activating the Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Tobacco Induced Diseases"
DOI: 10.18332/tid/146959
Abstract: INTRODUCTION Endothelial microparticles (EMPs) are partly associated with the progress of chronic obstructive pulmonary disease (COPD). We sought to measure the levels of EMPs in COPD patients and in human pulmonary microvascular endothelial cells (HPMECs)… read more here.
Keywords: hpmecs; apoptosis; expression; pecam emps ... See more keywords
Endothelial Microparticles Derived from Primary Pulmonary Microvascular Endothelial Cells Mediate Lung Inflammation in Chronic Obstructive Pulmonary Disease by Transferring microRNA-126
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s349818
Abstract: Background Extracellular vesicles (EVs) are considered to new types of intercellular communication media, and microRNA is one of the most common transferring components of EVs. This study aimed to explore the potential role of endothelial… read more here.
Keywords: inflammation; primary pulmonary; endothelial cells; lung inflammation ... See more keywords
Highly Pathogenic PRRSV-Infected Alveolar Macrophages Impair the Function of Pulmonary Microvascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14030452
Abstract: The porcine reproductive and respiratory syndrome virus (PRRSV), especially the highly pathogenic strains, can cause serious acute lung injury (ALI), characterized by extensive hemorrhage, inflammatory cells and serous fluid infiltration in the lung vascular system.… read more here.
Keywords: prrsv; endothelial cells; pulmonary microvascular; alveolar macrophages ... See more keywords
Regulation on Toll-like Receptor 4 and Cell Barrier Function by Rab26 siRNA-loaded DNA Nanovector in Pulmonary Microvascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2017 at "Theranostics"
DOI: 10.7150/thno.17584
Abstract: The small GTPase Rab26 is involved in multiple processes, such as vesicle-mediated secretion and autophagy. However, the mechanisms and functions of Rab26 in the human pulmonary microvascular endothelial cells (HPMVECs) are not clear. In this… read more here.
Keywords: sirna loaded; microvascular endothelial; rab26 sirna; endothelial cells ... See more keywords