Pulmonary neuroendocrine tumors: study of 266 cases focusing on clinicopathological characteristics, immunophenotype, and prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-022-03970-x
Abstract: Pulmonary neuroendocrine tumors (PNETs) consist of small-cell lung cancer (SCLC), large-cell neuroendocrine carcinoma (LCNEC), typical carcinoid (TC), and atypical carcinoid (AC). We aimed to analyze the immunophenotypic, metastatic, and prognostic risk factors for PNETs. A… read more here.
Keywords: neuroendocrine tumors; pulmonary neuroendocrine; prognosis; clinicopathological characteristics ... See more keywords
Pulmonary Neuroendocrine Cells: Sensors and Sentinels of the Lung.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.05.009
Abstract: Organisms have developed cellular "antennas" to sense, interpret, and integrate environmental stimuli. In a recent issue of Science, Sui et al. (2018) demonstrate that discrete clusters of pulmonary neuroendocrine cells in the lung can sense airborne… read more here.
Keywords: neuroendocrine cells; pulmonary neuroendocrine; cells sensors; sentinels lung ... See more keywords
Efficient Generation and Transcriptomic Profiling of Human iPSC-Derived Pulmonary Neuroendocrine Cells
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101083
Abstract: Summary Expansion of pulmonary neuroendocrine cells (PNECs) is a pathological feature of many human lung diseases. Human PNECs are inherently difficult to study due to their rarity ( read more here.
Keywords: neuroendocrine cells; efficient generation; pulmonary neuroendocrine; transcriptomic profiling ... See more keywords
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Granulomatous Inflammation Mimicking High-Grade Malignancy on FDG-PET/CT.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000001438
Abstract: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare form of preinvasive lung lesion associated with indolent carcinoid tumor formation. This disease is characterized by multiple small pulmonary nodules with low SUVmax on F-FDG… read more here.
Keywords: pulmonary neuroendocrine; idiopathic pulmonary; diffuse idiopathic; fdg pet ... See more keywords
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH): Prevalence, clinicopathological characteristics and survival outcome in a cohort of 311 patients with well‐differentiated lung neuroendocrine tumours
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13184
Abstract: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is considered to be a rare condition associated with lung neuroendocrine tumours (NET), and its natural history is poorly described. We aimed to assess the prevalence and clinicopathologic… read more here.
Keywords: idiopathic pulmonary; neuroendocrine cell; cell hyperplasia; pulmonary neuroendocrine ... See more keywords
Prognostic significance of PD-L1 expression and CD8+ T cell infiltration in pulmonary neuroendocrine tumors
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic Pathology"
DOI: 10.1186/s13000-018-0712-1
Abstract: BackgroundRecent research supports a significant role of immune checkpoint inhibitors in the treatment of solid tumors. However, relevant reports for programmed death-ligand 1 (PD-L1) and CD8+ tumor-infiltrating lymphocytes (TILs) in pulmonary neuroendocrine tumors (PNETs) have… read more here.
Keywords: cd8; pulmonary neuroendocrine; neuroendocrine tumors; expression ... See more keywords
The Fibrosis-Targeted Collagen/Integrins Gene Profile Predicts Risk of Metastasis in Pulmonary Neuroendocrine Neoplasms
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.706141
Abstract: Recently, collagen/integrin genes have shown promise as predictors of metastasis mainly in non-small cell lung cancer and breast cancer. However, it is unknown if these gene expression profiling differ in metastatic potential of pulmonary neuroendocrine… read more here.
Keywords: collagen; fibrosis; collagen integrin; pulmonary neuroendocrine ... See more keywords
Is the Morphological Subtype of Extra-Pulmonary Neuroendocrine Carcinoma Clinically Relevant?
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13164152
Abstract: Simple Summary Neuroendocrine carcinomas (NECs) represent the most aggressive subgroup of neuroendocrine neoplasms. Around 90% of NECs arise from the lung. The minority of NECs originating outside of the lung are called extra-pulmonary (EP)-NECs. Most… read more here.
Keywords: morphological subtype; index; pulmonary neuroendocrine; extra pulmonary ... See more keywords
Deep Learning Facilitates Distinguishing Histologic Subtypes of Pulmonary Neuroendocrine Tumors on Digital Whole-Slide Images
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071740
Abstract: Simple Summary Challenges persist in diagnosing pulmonary neuroendocrine tumors. Our case study shows that deep learning combined with convolutional neural networks has the potential to assist in the diagnosis of pulmonary neuroendocrine tumors from digital… read more here.
Keywords: tumors digital; lung; neuroendocrine tumors; deep learning ... See more keywords
Quantitative Airway Assessment of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) on CT as a Novel Biomarker
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12123096
Abstract: Objectives: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) occurs due to abnormal proliferation of pulmonary neuroendocrine cells. We hypothesized that performing a quantitative analysis of airway features on chest CT may reveal differences to matched… read more here.
Keywords: biomarker; dipnech; ratio; pulmonary neuroendocrine ... See more keywords
Proposing Specific Neuronal Epithelial-to-Mesenchymal Transition Genes as an Ancillary Tool for Differential Diagnosis among Pulmonary Neuroendocrine Neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13122309
Abstract: Pulmonary neuroendocrine neoplasms (PNENs) are currently classified into four major histotypes, including typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC), and small cell lung carcinoma (SCLC). This classification was designed to be… read more here.
Keywords: emt genes; mesenchymal transition; neuroendocrine neoplasms; epithelial mesenchymal ... See more keywords