Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis
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DOI: 10.1097/aln.0000000000003149
Abstract: Background: Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory… read more here.
Keywords: pulmonary sepsis; sepsis; lung; c5a ... See more keywords
Clinical Characteristics and Predictors of Mortality Differ Between Pulmonary and Abdominal Sepsis.
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DOI: 10.1097/shk.0000000000002151
Abstract: BACKGROUND Pulmonary and abdominal sepsis have pathophysiologically distinct phenotypes. This study aimed to compare their clinical characteristics and predictors of mortality. METHODS In this multicenter retrospective trial, 1,359 adult patients who fulfilled the Sepsis-3 criteria… read more here.
Keywords: sepsis; abdominal sepsis; mortality; day mortality ... See more keywords
Machine learning and murine models explain failures of clinical sepsis trials
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DOI: 10.1097/ta.0000000000003691
Abstract: All sepsis is not the same. There are differences in the inflammatory responses that result from intra-abdominal sepsis and gram-negative pneumonia models. HAT is beneficial in intra-abdominal sepsis but not in the pulmonary sepsis model.… read more here.
Keywords: sepsis; abdominal sepsis; sepsis trials; pna ... See more keywords
Association of Pulmonary Sepsis and Immune Checkpoint Inhibitors: A Pharmacovigilance Study
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DOI: 10.3390/cancers15010240
Abstract: Simple Summary This study investigates the association of pulmonary sepsis with immune checkpoint inhibitors by conducting an analysis using data from the Food and Drug Administration pharmacovigilance database. Compared to chemotherapy or targeted therapy, a… read more here.
Keywords: sepsis; checkpoint inhibitors; immune checkpoint; icis ... See more keywords