Interaction of pulmonary surfactant with silica and polycyclic aromatic hydrocarbons: Implications for respiratory health.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.02.002
Abstract: Understanding the interaction between pulmonary surfactant (PS) and inhalable pollutants is vital for risk assessment of respiratory health. Here, PS extracted from porcine lung (EPS) was used to investigate the interaction of PS with nano-silica… read more here.
Keywords: interaction pulmonary; pahs; silica; pulmonary surfactant ... See more keywords
Methods and models to investigate the physico-chemical functionality of pulmonary surfactant
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Colloid and Interface Science"
DOI: 10.1016/j.cocis.2021.101467
Abstract: Abstract The pulmonary surfactant (PS) is a complex mixture of lipids and proteins dispersed in the aqueous lining layer of the alveolar surface. Such a layer plays a key role in maintaining the proper lung… read more here.
Keywords: functionality; methods models; models investigate; pulmonary surfactant ... See more keywords
Phospholipid components of the synthetic pulmonary surfactant CHF5633 probed by fluorescence spectroscopy
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.10.045
Abstract: &NA; CHF5633 (Chiesi Farmaceutici, Italy) is a synthetic pulmonary surfactant currently under clinical development for the treatment of Respiratory Distress Syndrome in premature infants. The product is composed of phospholipids in liposomal organization, together with… read more here.
Keywords: chf5633; fluorescence; phospholipid components; pulmonary surfactant ... See more keywords
Pulmonary surfactant as a versatile biomaterial to fight COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2021.11.023
Abstract: The COVID-19 pandemic has wielded an enormous pressure on global health care systems, economics and politics. Ongoing vaccination campaigns effectively attenuate viral spreading, leading to a reduction of infected individuals, hospitalizations and mortality. Nevertheless, the… read more here.
Keywords: versatile biomaterial; surfactant versatile; pulmonary surfactant; covid ... See more keywords
Native supramolecular protein complexes in pulmonary surfactant: Evidences for SP-A/SP-B interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.103466
Abstract: Pulmonary surfactant is a lipid-protein complex which coats lung alveoli. It displays the essential function of reducing surface tension at the air-liquid interface, avoiding alveolar collapse during expiration. The optimized biophysical properties of surfactant rely… read more here.
Keywords: protein; complexes pulmonary; pulmonary surfactant; native supramolecular ... See more keywords
Pulmonary surfactant inhibition of nanoparticle uptake by alveolar epithelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-76332-7
Abstract: Pulmonary surfactant forms a sub-micrometer thick fluid layer that covers the surface of alveolar lumen and inhaled nanoparticles therefore come in to contact with surfactant prior to any interaction with epithelial cells. We investigate the… read more here.
Keywords: epithelial cells; microscopy; inhibition nanoparticle; pulmonary surfactant ... See more keywords
SP-D attenuates LPS-induced formation of human neutrophil extracellular traps (NETs), protecting pulmonary surfactant inactivation by NETs
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0662-5
Abstract: An exacerbated amount of neutrophil extracellular traps (NETs) can cause dysfunction of systems during inflammation. However, host proteins and factors that suppress NET formation (NETosis) are not clearly identified. Here we show that an innate… read more here.
Keywords: neutrophil extracellular; formation; pulmonary surfactant; lps mediated ... See more keywords
Physicochemical properties of nanoparticles affect translocation across pulmonary surfactant monolayer
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Physics"
DOI: 10.1080/00268976.2017.1351005
Abstract: ABSTRACT Interaction between nanoparticles (NPs) and pulmonary surfactant monolayer is one of the most important parts in NP-based pulmonary drug delivery system, which can affect the result of the inhaled nano-drugs and their potential efficacy.… read more here.
Keywords: translocation across; across pulmonary; surfactant monolayer; pulmonary surfactant ... See more keywords
Surfactant Proteins SP-B and SP-C in Pulmonary Surfactant Monolayers: Physical Properties Controlled by Specific Protein–Lipid Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Langmuir"
DOI: 10.1101/2022.12.12.520108
Abstract: The lining of the alveoli is covered by pulmonary surfactant, a complex mixture of surface-active lipids and proteins that enables efficient gas exchange between inhaled air and the circulation. Despite decades of advancements in the… read more here.
Keywords: lipid interactions; microscopy; lipids proteins; surfactant proteins ... See more keywords
miR‐20a‐5p regulates pulmonary surfactant gene expression in alveolar type II cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14639
Abstract: MicroRNA (miRNA) critically controls gene expression in many biological processes, including lung growth and pulmonary surfactant biosynthesis. The present study was conducted to investigate whether miR‐20a‐5p had such regulatory functions on alveolar type II (AT‐II)… read more here.
Keywords: mir 20a; surfactant gene; gene expression; pulmonary surfactant ... See more keywords
Exogenous pulmonary surfactant in COVID-19 ARDS. The similarities to neonatal RDS suggest a new scenario for an ‘old’ strategy
Sign Up to like & getrecommendations! Published in 2021 at "BMJ Open Respiratory Research"
DOI: 10.1136/bmjresp-2020-000867
Abstract: Acute respiratory distress syndrome (ARDS) related to SARS-CoV-2 infection has some unusual characteristics that differentiate it from the pathophysiology described in the more ‘typical’ ARDS. Among multiple hypotheses, a close similarity has been suggested between… read more here.
Keywords: surfactant covid; pulmonary surfactant; covid; covid ards ... See more keywords