Pannexin 1-a novel regulator of acute hypoxic pulmonary vasoconstriction.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab326
Abstract: AIMS Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to alveolar hypoxia that diverts blood flow from poorly ventilated to better aerated lung areas to optimize ventilation-perfusion matching. Yet, the exact sensory and signaling mechanisms… read more here.
Keywords: pulmonary vasoconstriction; panx1; hypoxic pulmonary; hypoxic ... See more keywords
Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvx076
Abstract: Aims Hypoxic pulmonary vasoconstriction (HPV) redistributes blood flow from poorly ventilated to better aerated areas in the lung, thereby optimizing ventilation-perfusion ratio (V/Q). Pulmonary artery smooth muscle cell (PASMC) contraction in response to hypoxia is… read more here.
Keywords: pulmonary vasoconstriction; response; vasoconstriction; hypoxic pulmonary ... See more keywords
Hypoxic pulmonary vasoconstriction: Building a solid base
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Physiology"
DOI: 10.1113/ep087179
Abstract: Hypoxic vasoconstriction is a response that is seen in the pulmonary circulation but not in any other vascular bed in the body. By diverting blood flow away from less well-ventilated regions in the lung, it… read more here.
Keywords: pulmonary vasoconstriction; response; vasoconstriction; hypoxic pulmonary ... See more keywords
The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aau0296
Abstract: Perfusion-ventilation matching in the lungs requires AMPK-α1 and AMPK-α2 activation downstream of LKB1. Hypoxia amps AMPK Most arteries in the body vasodilate in response to hypoxia. In contrast, pulmonary arteries constrict in response to hypoxia… read more here.
Keywords: pulmonary vasoconstriction; ampk; vasoconstriction; hypoxic pulmonary ... See more keywords
Attenuation of human hypoxic pulmonary vasoconstriction by acetazolamide and methazolamide.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00509.2018
Abstract: RATIONALE Acetazolamide, a carbonic anhydrase inhibitor used for preventing altitude illness attenuates hypoxic pulmonary vasoconstriction (HPV) while improving oxygenation. Methazolamide, an analog of acetazolamide, is more lipophilic, has a longer half-life, and activates a major… read more here.
Keywords: pulmonary vasoconstriction; plasma antioxidant; hypoxic pulmonary; hypoxia ... See more keywords
Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction".
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/circresaha.119.315826
Abstract: In Response: This response letter addresses discussion initiated by Hüttemann et al in their Letter to the Editor, in response to our article “Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute… read more here.
Keywords: response; oxygen sensing; pulmonary vasoconstriction; hypoxic pulmonary ... See more keywords
Src and Epidermal Growth Factor Receptor: Novel Partners in Mediating Chronic Hypoxia–induced Pulmonary Artery Hypertension
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2019-0230ed
Abstract: Increased activity of the RhoA/Rho kinase (RhoA/ROCK) signaling pathway is a key feature in the development of pulmonary arterial hypertension (PAH) and the associated pulmonary vascular remodeling under various pathophysiological conditions, including chronic hypoxia. Both… read more here.
Keywords: hypoxia; src; chronic hypoxia; pulmonary vasoconstriction ... See more keywords
Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice
Sign Up to like & getrecommendations! Published in 2018 at "Pulmonary Circulation"
DOI: 10.1177/2045894018808240
Abstract: We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These… read more here.
Keywords: pulmonary vasoconstriction; intra acinar; acinar; nadph oxidase ... See more keywords
Dysregulation of the Nitric Oxide/Dimethylarginine Pathway in Hypoxic Pulmonary Vasoconstriction—Molecular Mechanisms and Clinical Significance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.835481
Abstract: The pulmonary circulation responds to hypoxia with vasoconstriction, a mechanism that helps to adapt to short-lived hypoxic episodes. When sustained, hypoxic pulmonary vasoconstriction (HPV) may become deleterious, causing right ventricular hypertrophy and failure, and contributing… read more here.
Keywords: vasoconstriction; dysregulation nitric; nitric oxide; pulmonary vasoconstriction ... See more keywords