High amplitude and low frequency cyclic mechanical strain promotes degeneration of human nucleus pulposus cells via the NF‐κB p65 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26551
Abstract: Disc degeneration alters the structure and function of intervertebral discs and is the basis of spinal degenerative diseases. To establish the molecular mechanism of intervertebral disc degeneration caused by mechanical strain, this study examined the… read more here.
Keywords: human nucleus; cms; pulposus cells; pulposus ... See more keywords
lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29129
Abstract: Intervertebral disc degeneration (IDD) is a complex and chronic disease that involves disc cell senescence, death, and extracellular matrix (ECM) degradation. HOTAIR, a long non‐coding RNA (lncRNA) is reportedly associated with autophagy, whereas autophagy is… read more here.
Keywords: apoptosis senescence; hotair; senescence; pulposus cells ... See more keywords
Baicalein Inhibits the IL-1β-Induced Inflammatory Response in Nucleus Pulposus Cells and Attenuates Disc Degeneration In vivo
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-00965-8
Abstract: Intervertebral disc degeneration (IDD) is widely considered one of the main causes of low back pain, which is a chronic progressive disease closely related to inflammation and degeneration of nucleus pulposus (NP) cells. Baicalein is… read more here.
Keywords: inflammatory response; degeneration; pulposus cells; nucleus pulposus ... See more keywords
Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca2+/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106681
Abstract: Studying and understanding the mechanism of inflammation in nucleus pulposus is the key to understand and prevent intervertebral disc degeneration. We propose a model of mechanical sensitive ion channel Piezo1 mediated inflammation of nucleus pulposus… read more here.
Keywords: ca2 pathway; nucleus pulposus; piezo1; pulposus cells ... See more keywords
MicroRNA-137 inhibits the inflammatory response and extracellular matrix degradation in lipopolysaccharide-stimulated human nucleus pulposus cells by targeting activin a receptor type I
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2042987
Abstract: ABSTRACT This study aimed to investigate the role played by microRNA (miR)-137 in intervertebral disc degeneration via targeting activin A receptor type I (ACVR1) and the underlying mechanism. Human nucleus pulposus cells were exposed to… read more here.
Keywords: pulposus; extracellular matrix; type; nucleus pulposus ... See more keywords
Long intergenic non-coding RNA -00917 regulates the proliferation, inflammation, and pyroptosis of nucleus pulposus cells via targeting miR-149-5p/NOD-like receptor protein 1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2043100
Abstract: ABSTRACT Intervertebral disc degeneration (IDD) has caused great trouble in people’s lives. Dysregulated long noncoding RNAs (lncRNAs) are closely linked to IDD progression. Our study aims to analyze the role of LINC00917 in the progression… read more here.
Keywords: pyroptosis; mir 149; nucleus pulposus; pulposus cells ... See more keywords
Omentin-1 alleviate interleukin-1β(IL-1β)-induced nucleus pulposus cells senescence
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2084495
Abstract: ABSTRACT One of the main causes of low back pain (LBP) and degenerative musculoskeletal disorders is intervertebral disc degeneration (IVDD). Inflammation-associated senescence of Human nucleus pulposus cells (HNPCs) plays an essential function in the disease… read more here.
Keywords: omentin; ivdd; senescence; nucleus pulposus ... See more keywords
Dynamic Pressure Stimulation Upregulates Collagen II and Aggrecan in Nucleus Pulposus Cells Through Calcium Signaling.
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DOI: 10.1097/brs.0000000000004286
Abstract: STUDY DESIGN An in vitro study to investigate the effect of pressure stimulation on nucleus pulposus (NP) cells. OBJECTIVE The aim of this study was to investigate the question whether physical stimulation can be leveraged… read more here.
Keywords: pressure stimulation; nucleus pulposus; pressure; dynamic pressure ... See more keywords
Regenerative Capability of Human Nucleus Pulposus Cells in Degenerated Disc Under Hydrostatic Pressure Mimicking Physiologically Relevant Intradiscal Pressure In Vitro
Sign Up to like & getrecommendations! Published in 2023 at "Spine"
DOI: 10.1097/brs.0000000000004530
Abstract: Study Design. Isolated human nucleus pulposus (hNP) cells from the degenerated intervertebral disc (IVD) were incubated under hydrostatic pressure (HP) and evaluated for regenerative potential. Objectives. To characterize metabolic turnover in hNP cells isolated from… read more here.
Keywords: human nucleus; pulposus cells; pressure; nucleus pulposus ... See more keywords
The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells
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DOI: 10.1111/cpr.12987
Abstract: Inappropriate or excessive compression applied to intervertebral disc (IVD) contributes substantially to IVD degeneration. The actomyosin system plays a leading role in responding to mechanical stimuli. In the present study, we investigated the roles of… read more here.
Keywords: compression; roles myosin; pulposus cells; nucleus pulposus ... See more keywords
Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration
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DOI: 10.1111/jcmm.13586
Abstract: Spermidine has therapeutic effects in many diseases including as heart diastolic function, myopathic defects and neurodegenerative disorders via autophagy activation. Autophagy has been found to mitigate cell apoptosis in intervertebral disc degeneration (IDD). Accordingly, we… read more here.
Keywords: nucleus pulposus; pulposus cells; disc degeneration; spermidine ... See more keywords