Pseudouridimycin—A Potent Nucleoside Inhibitor of the RNA Polymerase Beta Prime Subunit of Streptococcus pyogenes
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07805
Abstract: Streptococcus pyogenes (group A streptococcus, GAS), a Gram-positive bacterium, is a major cause of mild to severe life-threatening infections. Antibacterial resistance to penicillin and macrolides poses a major threat in the treatment of GAS and… read more here.
Keywords: polymerase; rna polymerase; subunit; streptococcus pyogenes ... See more keywords
NORAD-induced Pumilio phase separation is required for genome stability.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03633-w
Abstract: Liquid-liquid phase separation is a major mechanism of subcellular compartmentalization1,2. Although the segregation of RNA into phase-separated condensates broadly affects RNA metabolism3,4, whether and how specific RNAs use phase separation to regulate interacting factors such… read more here.
Keywords: phase separation; mechanism; rna; pum ... See more keywords
The target specificity of the RNA binding protein Pumilio is determined by distinct co-factors
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DOI: 10.1042/bsr20190099
Abstract: Puf family proteins are translational regulators essential to a wide range of biological processes, including cell fate specification, stem cell self-renewal, and neural function. Yet, despite being associated with hundreds of RNAs, the underlying mechanisms… read more here.
Keywords: target; pum; target specificity; pumilio ... See more keywords
Upper Tract Urinary Cancer Recurrence after Radical Cystectomy: Risk Assessment of Intraoperative Frozen Section.
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DOI: 10.1159/000521804
Abstract: INTRODUCTION Upper tract urinary cancer recurrence (UTUCR) after radical cystectomy (RC) is outcome-limiting. Surgical recommendations on intraoperative performance of frozen section analysis (FSA) and management of positive ureteral margin (PUM) are lacking. METHODS 634 RC… read more here.
Keywords: cancer; risk; pum; tract urinary ... See more keywords
Structural Insights into the Role of Pseudouridimycin Binding in Disruption of Bacterial RNA Polymerase Bridge Helix Conformational Arrangement.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201023666220511211433
Abstract: BACKGROUND The bridge helix (BH) is a crucial region involved in bacterial RNA polymerase (RNAP) catalysis. It plays an essential role in the nucleotide addition cycle (NAC) by performing many modulated rearrangements and conformational changes.… read more here.
Keywords: role; bacterial rna; bridge helix; pum ... See more keywords