Functions, mechanisms and regulation of Pumilio/Puf family RNA binding proteins: a comprehensive review
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-05142-6
Abstract: The Pumilio (Pum)/Puf family proteins are ubiquitously present across eukaryotes, including yeast, plants and humans. They generally bind to the 3′ untranslated regions of single stranded RNA targets in a sequence specific manner and destabilize… read more here.
Keywords: pumilio; functions mechanisms; puf family; mechanisms regulation ... See more keywords
A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.04.012
Abstract: High-throughput methodologies have enabled routine generation of RNA target sets and sequence motifs for RNA-binding proteins (RBPs). Nevertheless, quantitative approaches are needed to capture the landscape of RNA-RBP interactions responsible for cellular regulation. We have… read more here.
Keywords: pumilio; predictive model; rna; rna binding ... See more keywords
The target specificity of the RNA binding protein Pumilio is determined by distinct co-factors
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20190099
Abstract: Puf family proteins are translational regulators essential to a wide range of biological processes, including cell fate specification, stem cell self-renewal, and neural function. Yet, despite being associated with hundreds of RNAs, the underlying mechanisms… read more here.
Keywords: target; pum; target specificity; pumilio ... See more keywords
PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac499
Abstract: Abstract DICER1 syndrome is a cancer pre-disposition disorder caused by mutations that disrupt the function of DICER1 in miRNA processing. Studying the molecular, cellular and oncogenic effects of these mutations can reveal novel mechanisms that… read more here.
Keywords: dicer1; mirna processing; control; rna ... See more keywords
Pumilio directs deadenylation-associated translational repression of the cyclin-dependent kinase 1 activator RGC-32
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky038
Abstract: Abstract Response gene to complement-32 (RGC-32) activates cyclin-dependent kinase 1, regulates the cell cycle and is deregulated in many human tumours. We previously showed that RGC-32 expression is upregulated by the cancer-associated Epstein-Barr virus (EBV)… read more here.
Keywords: ebv; cyclin dependent; pumilio; rgc ... See more keywords
The topography of rods, cones and intrinsically photosensitive retinal ganglion cells in the retinas of a nocturnal (Micaelamys namaquensis) and a diurnal (Rhabdomys pumilio) rodent
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0202106
Abstract: We used immunocytochemistry to determine the presence and topographical density distributions of rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs) in the four-striped field mouse (Rhabdomys pumilio) and the Namaqua rock mouse (Micaelamys namaquensis).… read more here.
Keywords: topography; rods cones; namaquensis; pumilio ... See more keywords
A FACS-based screening strategy to assess sequence-specific RNA-binding of Pumilio protein variants in E. coli
Sign Up to like & getrecommendations! Published in 2017 at "Biological Chemistry"
DOI: 10.1515/hsz-2016-0214
Abstract: Abstract Sequence-specific and programmable binding of proteins to RNA bears the potential to detect and manipulate target RNAs. Applications include analysis of subcellular RNA localization or post-transcriptional regulation but require sequence-specificity to be readily adjustable… read more here.
Keywords: sequence specific; pumilio; rna; facs based ... See more keywords