Absence, loss-of-function, or inhibition of Escherichia coli AcrB does not increase expression of other efflux pump genes supporting the discovery of AcrB inhibitors as antibiotic adjuvants
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DOI: 10.1093/jac/dkab452
Abstract: Abstract Objectives To determine whether expression of efflux pumps and antibiotic susceptibility are altered in Escherichia coli in response to efflux inhibition. Methods The promoter regions of nine efflux pump genes (acrAB, acrD, acrEF, emrAB,… read more here.
Keywords: inhibition; pump; expression efflux; pump genes ... See more keywords
Detection of AdeAB, TetA, and TetB efflux pump genes in clinical isolates of tetracycline-resistant Acinetobacter baumannii from patients of Suez Canal University Hospitals
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DOI: 10.1186/s12866-024-03735-1
Abstract: Acinetobacter baumannii is an opportunistic bacteria associated primarily with hospital-acquired infections. Its tendency to acquire or donate resistance genes to neighboring bacteria is a major concern. Tetracyclines have shown promise in treating A. baumannii infections,… read more here.
Keywords: detection; pump genes; efflux pump; pump ... See more keywords
Evaluation of Antibiotic Resistance and adeABC, adeR, adeS Efflux Pump Genes among Foodborne and Clinical Acinetobacter spp. in Türkiye
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DOI: 10.18502/ijph.v51i12.11466
Abstract: Background: The adeABC efflux pump has a crucial role in the resistance of Acinetobacter baumannii strains to antimicrobial agents; it is encoded by adeABC, adeR, adeS genes. We evaluated antibiotic resistance, efflux pump genes, clonal… read more here.
Keywords: pump genes; ader ades; resistance; efflux pump ... See more keywords
Expression of the Fluoroquinolones Efflux Pump Genes acrA and mdfA in Urinary Escherichia coli Isolates.
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DOI: 10.5604/17331331.1234990
Abstract: Escherichia coli is one of the most frequent causes of urinary tract infections. Efflux system overexpression is reported to contribute to E. coli resistance to several antibiotics. Our aim in this study was to investigate… read more here.
Keywords: acra mdfa; pump genes; escherichia coli; efflux pump ... See more keywords