Scalable and Chromatography-Free Synthesis of Efflux Pump Inhibitor Phenylalanine Arginine β-Naphthylamide for its Validation in Wild-Type Bacterial Strains.
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DOI: 10.1002/cmdc.202300128
Abstract: Phenylalanine arginine β-naphthylamine, or PAβN, is a C-terminus capped dipeptide discovered as an RND-type efflux pump inhibitor (EPI) in 1999. Since then, PAβN has become a standard tool compound in EPI research and development. Despite… read more here.
Keywords: synthesis; efflux pump; phenylalanine arginine; type bacterial ... See more keywords
Confounded association between proton pump inhibitor use and risk of biliary tract cancer: Result from three cohorts.
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DOI: 10.1002/ijc.34572
Abstract: Recent epidemiological studies suggested that proton pump inhibitor (PPI) use was associated with an increased risk of biliary tract cancer (BTC), however, confounders were not adequately controlled. Our study aimed to evaluate PPI use and… read more here.
Keywords: btc; proton pump; pump inhibitor; risk ... See more keywords
Evaluation of the effects of formulation, food, or a proton-pump inhibitor on the pharmacokinetics of glasdegib (PF-04449913) in healthy volunteers: a randomized phase I study
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DOI: 10.1007/s00280-018-3748-8
Abstract: PurposeTo demonstrate the bioequivalence of the planned maleate salt-based commercial glasdegib tablet formulation [International Council for Harmonization (ICH) glasdegib] to the clinical di-hydrochloride (di-HCl) salt-based glasdegib formulation (di-HCl glasdegib). Additionally, to estimate the effects of… read more here.
Keywords: glasdegib; pump inhibitor; formulation; fasted conditions ... See more keywords
The efflux pump inhibitor tetrandrine exhibits synergism with fluconazole or voriconazole against Candida parapsilosis
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DOI: 10.1007/s11033-019-05020-1
Abstract: In the last two decades, with the wide use of azoles, antifungal resistance among Candida parapsilosis has considered a matter of concern worldwide. The aim of this study is to evaluate the antifungal potentials of… read more here.
Keywords: efflux pump; candida parapsilosis; pump inhibitor; synergism ... See more keywords
Hemorrhagic polyps formed like fundic gland polyps during long-term proton pump inhibitor administration
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Journal of Gastroenterology"
DOI: 10.1007/s12328-017-0756-x
Abstract: We report a rare case of hemorrhagic gastric polyps resulting in anemia during long-term proton pump inhibitor (PPI) administration that endoscopically looked like a fundic gland polyp (FGP). A 44-year-old man presented complaining of anemia… read more here.
Keywords: administration; term proton; long term; pump inhibitor ... See more keywords
[Atrial fibrillation and QT prolongation due to proton pump inhibitor-induced hypomagnesemia].
Sign Up to like & getrecommendations! Published in 2020 at "Annales de cardiologie et d'angeiologie"
DOI: 10.1016/j.ancard.2020.07.016
Abstract: Proton pump inhibitors are widely prescribed but their long-term use can expose patients to adverse effects. Some of these are not very well known, including hypomagnesemia. Hypomagnesemia can be manifested by cardiac complications such as… read more here.
Keywords: atrial fibrillation; pump inhibitor; proton; proton pump ... See more keywords
Efflux pump inhibitor combined with ofloxacin decreases MRSA biofilm formation by regulating the gene expression of NorA and quorum sensing
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DOI: 10.1039/d2ra06696c
Abstract: Carbonyl cyanide p-nitrophenylhydrazone (2e) displayed a lone or synergistic efficacy against MRSA (RSC Adv., 2020, 10, 17854). In this work, the synergistic mechanism of 2e with ofloxacin was studied. MRSA2858 had potential for biofilm formation,… read more here.
Keywords: biofilm formation; nora quorum; efflux pump; combined ofloxacin ... See more keywords
In silico screening and in vitro validation of phytocompounds as multidrug efflux pump inhibitor against E. coli
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DOI: 10.1080/07391102.2022.2029564
Abstract: Abstract Multiple drug resistance (MDR) in bacteria has increased globally in recent times. This has reduced the efficacy of antibiotics and increasing the rate of therapeutic failure. Targeting efflux pump by natural and synthetic compounds… read more here.
Keywords: silico screening; screening vitro; chlorogenic acid; efflux pump ... See more keywords
Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers
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DOI: 10.1097/mcg.0000000000001357
Abstract: Supplemental Digital Content is available in the text. read more here.
Keywords: plus proton; proton pump; pump inhibitor;
Proton Pump Inhibitor Prescribing and Monitoring Patterns Among Gastroenterology Practitioners.
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DOI: 10.1097/mcg.0000000000001623
Abstract: GOALS The aim was to quantify proton pump inhibitor (PPI) practice habits among gastroenterology (GI) practitioners. BACKGROUND Reports of side effects have prompted patients and practitioners alike to discontinue PPI use. Emerging evidence-based literature on… read more here.
Keywords: pump inhibitor; gastroenterology; proton pump; side effects ... See more keywords
Proton Pump Inhibitor and H2 Blocker-Associated Acute Interstitial Nephritis in a Renal Allograft.
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DOI: 10.1097/mjt.0000000000000641
Abstract: preference in acute life-threatening tracheobronchial obstruction with radiolucent foreign bodies. In addition, rigid bronchoscopy provides better grasp for fragmented, partially absorbed or macerated pills as seen in our case, making it the procedure of choice… read more here.
Keywords: associated acute; pump inhibitor; inhibitor blocker; acute interstitial ... See more keywords