Na/K Pump Mutations Associated with Primary Hyperaldosteronism Cause Loss of Function.
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DOI: 10.1021/acs.biochem.9b00051
Abstract: Primary hyperaldosteronism (Conn's syndrome), a common cause of secondary hypertension, is frequently produced by unilateral aldosterone-producing adenomas that carry mutations in ion-transporting genes, including ATP1A1, encoding the Na/K pump's α1 subunit. Whether Na/K pump mutant-mediated… read more here.
Keywords: hyperaldosteronism; pump; primary hyperaldosteronism; inward currents ... See more keywords