Aggregation and Particle Formation During Pumping of an Antibody Formulation are Controlled by Electrostatic Interactions between Pump Surfaces and Protein Molecules.
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DOI: 10.1016/j.xphs.2020.01.023
Abstract: Aggregates and particles may be generated by positive displacement piston pumps during fill-finishing operations for protein formulations. We investigated potential factors that might contribute to aggregation in intravenous IgG (IVIG) formulations during pumping, including electrostatic… read more here.
Keywords: protein molecules; electrostatic interactions; pump surfaces; particle formation ... See more keywords