The coevolution of large and small terminases of bacteriophages is a result of purifying selection leading to phenotypic stabilization.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.09.004
Abstract: Genome packaging in many dsDNA phages requires a series of precisely coordinated actions of two phage-coded proteins, namely, large terminase (TerL) and small terminase (TerS) with DNA and ATP, and with each other. Despite the… read more here.
Keywords: coevolution large; phage; terl ters; purifying selection ... See more keywords
Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23508-x
Abstract: Several evolutionary mechanisms alter the fate of mutations and genes within populations based on their exhibited functional effects. To understand the underlying mechanisms involved in the evolution of the cellular stress response, a very conserved… read more here.
Keywords: gene; stress; gene conversion; purifying selection ... See more keywords
The Role of Small RNA-Based Epigenetic Silencing for Purifying Selection on Transposable Elements in Capsella grandiflora
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evx206
Abstract: Abstract To avoid negative effects of transposable element (TE) proliferation, plants epigenetically silence TEs using a number of mechanisms, including RNA-directed DNA methylation. These epigenetic modifications can extend outside the boundaries of TE insertions and… read more here.
Keywords: gene regulation; epigenetic silencing; selection; capsella grandiflora ... See more keywords
MTR3D: identifying regions within protein tertiary structures under purifying selection
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab428
Abstract: Abstract The identification of disease-causal variants is non-trivial. By mapping population variation from over 448,000 exome and genome sequences to over 81,000 experimental structures and homology models of the human proteome, we have calculated both… read more here.
Keywords: protein; mtr3d; variation; missense ... See more keywords
Emergence of SARS-CoV-2 through recombination and strong purifying selection
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DOI: 10.1126/sciadv.abb9153
Abstract: Frequent recombination and strong purifying selection facilitate the cross-species transmission of coronaviruses to humans. COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring… read more here.
Keywords: sars cov; recombination; strong purifying; purifying selection ... See more keywords
Cell-Derived Viral Genes Evolve under Stronger Purifying Selection in Rhadinoviruses
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.00359-18
Abstract: Viruses and hosts have been shown to capture genes from one another as part of the evolutionary arms race. Such genes offer a natural experiment on the effects of evolutionary pressure, since the same gene… read more here.
Keywords: derived viral; genes evolve; host; viral genes ... See more keywords
Discovery of positive and purifying selection in metagenomic time series of hypermutator microbial populations
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010324
Abstract: A general method to infer both positive and purifying selection during the real-time evolution of hypermutator pathogens would be broadly useful. To this end, we introduce a simple test to infer mode of selection (STIMS)… read more here.
Keywords: purifying selection; positive purifying; time; selection ... See more keywords
The Effect of Strong Purifying Selection on Genetic Diversity
Sign Up to like & getrecommendations! Published in 2018 at "Genetics"
DOI: 10.1534/genetics.118.301058
Abstract: Negative selection is a ubiquitous evolutionary force, but its effects on diversity in large samples are poorly understood. Cvijović, Good, and Desai obtain simple analytical expressions for the whole population site frequency spectrum.... Purifying selection… read more here.
Keywords: diversity; genetic diversity; frequency; selection ... See more keywords
Genetic Drift and Purifying Selection Shaped Mitochondrial Genome Variation in the High Royal Jelly-Producing Honeybee Strain (Apis mellifera ligustica)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.835967
Abstract: Mitochondrial genomes (mitogenomes) are involved in cellular energy metabolism and have been shown to undergo adaptive evolution in organisms with increased energy-consuming activities. The genetically selected high royal jelly-producing bees (RJBs, Apis mellifera ligustica) in… read more here.
Keywords: purifying selection; jelly producing; royal jelly; genetic drift ... See more keywords
Natural selection and repeated patterns of molecular evolution following allopatric divergence
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DOI: 10.7554/elife.45199
Abstract: Although geographic isolation is a leading driver of speciation, the tempo and pattern of divergence at the genomic level remain unclear. We examine genome-wide divergence of putatively single-copy orthologous genes (POGs) in 20 allopatric species/variety… read more here.
Keywords: abundance pogs; purifying selection; selection repeated; divergence ... See more keywords