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   Articles with "purifying selection" as a keyword



T cell activation contributes to purifying selection against the MELAS‐associated m.3243A>G pathogenic variant in blood

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recommendations! Published in 2024 at "Journal of Inherited Metabolic Disease"

DOI: 10.1002/jimd.12726

Abstract: T cells have been shown to maintain a lower percentage (heteroplasmy) of the pathogenic m.3243A>G variant (MT‐TL1, associated with maternally inherited diabetes and deafness [MIDD] and mitochondrial encephalomyopathy with lactic acidosis and stroke‐like episodes [MELAS]).… read more here.

Keywords: cell activation; heteroplasmy; selection; purifying selection ... See more keywords

The coevolution of large and small terminases of bacteriophages is a result of purifying selection leading to phenotypic stabilization.

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recommendations! Published in 2021 at "Virology"

DOI: 10.1016/j.virol.2021.09.004

Abstract: Genome packaging in many dsDNA phages requires a series of precisely coordinated actions of two phage-coded proteins, namely, large terminase (TerL) and small terminase (TerS) with DNA and ATP, and with each other. Despite the… read more here.

Keywords: coevolution large; phage; terl ters; purifying selection ... See more keywords

Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-23508-x

Abstract: Several evolutionary mechanisms alter the fate of mutations and genes within populations based on their exhibited functional effects. To understand the underlying mechanisms involved in the evolution of the cellular stress response, a very conserved… read more here.

Keywords: gene; stress; gene conversion; purifying selection ... See more keywords

The Role of Small RNA-Based Epigenetic Silencing for Purifying Selection on Transposable Elements in Capsella grandiflora

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recommendations! Published in 2017 at "Genome Biology and Evolution"

DOI: 10.1093/gbe/evx206

Abstract: Abstract To avoid negative effects of transposable element (TE) proliferation, plants epigenetically silence TEs using a number of mechanisms, including RNA-directed DNA methylation. These epigenetic modifications can extend outside the boundaries of TE insertions and… read more here.

Keywords: gene regulation; epigenetic silencing; selection; capsella grandiflora ... See more keywords

MTR3D: identifying regions within protein tertiary structures under purifying selection

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recommendations! Published in 2021 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkab428

Abstract: Abstract The identification of disease-causal variants is non-trivial. By mapping population variation from over 448,000 exome and genome sequences to over 81,000 experimental structures and homology models of the human proteome, we have calculated both… read more here.

Keywords: protein; mtr3d; variation; missense ... See more keywords

Phylodynamics beyond neutrality: the impact of incomplete purifying selection on viral phylogenies and inference

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recommendations! Published in 2024 at "Philosophical Transactions of the Royal Society B: Biological Sciences"

DOI: 10.1098/rstb.2023.0314

Abstract: Viral phylodynamics focuses on using sequence data to make inferences about the population dynamics of viral infectious diseases. These inferences commonly include estimation of the viral growth rate, the reproduction number, and the time of… read more here.

Keywords: purifying selection; phylodynamic inference; incomplete purifying; phylodynamics beyond ... See more keywords

Emergence of SARS-CoV-2 through recombination and strong purifying selection

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recommendations! Published in 2020 at "Science Advances"

DOI: 10.1126/sciadv.abb9153

Abstract: Frequent recombination and strong purifying selection facilitate the cross-species transmission of coronaviruses to humans. COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring… read more here.

Keywords: sars cov; recombination; strong purifying; purifying selection ... See more keywords

Cell-Derived Viral Genes Evolve under Stronger Purifying Selection in Rhadinoviruses

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recommendations! Published in 2018 at "Journal of Virology"

DOI: 10.1128/jvi.00359-18

Abstract: Viruses and hosts have been shown to capture genes from one another as part of the evolutionary arms race. Such genes offer a natural experiment on the effects of evolutionary pressure, since the same gene… read more here.

Keywords: derived viral; genes evolve; host; viral genes ... See more keywords

Discovery of positive and purifying selection in metagenomic time series of hypermutator microbial populations

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recommendations! Published in 2022 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1010324

Abstract: A general method to infer both positive and purifying selection during the real-time evolution of hypermutator pathogens would be broadly useful. To this end, we introduce a simple test to infer mode of selection (STIMS)… read more here.

Keywords: purifying selection; positive purifying; time; selection ... See more keywords
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The Effect of Strong Purifying Selection on Genetic Diversity

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recommendations! Published in 2018 at "Genetics"

DOI: 10.1534/genetics.118.301058

Abstract: Negative selection is a ubiquitous evolutionary force, but its effects on diversity in large samples are poorly understood. Cvijović, Good, and Desai obtain simple analytical expressions for the whole population site frequency spectrum.... Purifying selection… read more here.

Keywords: diversity; genetic diversity; frequency; selection ... See more keywords

Genetic Drift and Purifying Selection Shaped Mitochondrial Genome Variation in the High Royal Jelly-Producing Honeybee Strain (Apis mellifera ligustica)

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recommendations! Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.835967

Abstract: Mitochondrial genomes (mitogenomes) are involved in cellular energy metabolism and have been shown to undergo adaptive evolution in organisms with increased energy-consuming activities. The genetically selected high royal jelly-producing bees (RJBs, Apis mellifera ligustica) in… read more here.

Keywords: purifying selection; jelly producing; royal jelly; genetic drift ... See more keywords