Inhibiting Erastin‐Induced Ferroptotic Cell Death by Purine‐Based Chelators
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100654
Abstract: Ferroptosis is a cell death event caused by increased lipid peroxidation leading to iron‐dependent oxidative stress and is associated with a wide variety of diseases. In recent years, ferroptosis inhibition has emerged as a novel… read more here.
Keywords: cell death; cell; erastin induced; purine ... See more keywords
Computer-assisted in vitro Reconstitution of Purine Degradation Pathway to Lower the Purine Content in Food.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12069
Abstract: BACKGROUND With the increasing prevalence of gout and its etiological hyperuricemia, dietary control on gout based on low-purine food according to patients' eating habits is becoming a better choice compared to the existing drug treatment… read more here.
Keywords: computer assisted; content food; food; purine ... See more keywords
1H and 13C assignments of 6‐, 8‐, 9‐ substituted purines
Sign Up to like & getrecommendations! Published in 2018 at "Magnetic Resonance in Chemistry"
DOI: 10.1002/mrc.4743
Abstract: Purines are heterocyclic aromatic organic compounds consisting of two 5‐ and 6‐membered fused rings containing nitrogen. They are present in numerous compounds, including natural products, with potent biological activity. Purine analogs are used for the… read more here.
Keywords: chemistry; substituted purines; 13c assignments; purine ... See more keywords
Purine tautomeric preferences and bond-length alternation in relation with protonation-deprotonation and alkali metal cationization
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-020-4343-6
Abstract: Quantum chemical calculations were carried out for deprotonated ( P − ) and protonated purine ( PH + ) and for adducts with one alkali metal cation ( P − M + and PM +… read more here.
Keywords: alkali metal; protonation; cationization; protonation deprotonation ... See more keywords
Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.07.054
Abstract: An 8-oxopurine-6-carboxamide compound (1a) was previously identified as an inhibitor of non-small cell lung cancer (NSCLC). In this study, more than 30 purine-6-carboxamide derivatives with variations at the C2, N7, C8, and N9 positions were… read more here.
Keywords: non small; cell; purine; lung cancer ... See more keywords
Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113101
Abstract: The kinetoplastid parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are the causative agents of neglected tropical diseases with a serious burden in several parts of the world. These parasites are incapable of synthesizing purines… read more here.
Keywords: collection purine; antikinetoplastid agents; evaluation collection; synthesis evaluation ... See more keywords
Hypoxanthine Guanine Phosphoribosyltransferase expression is negatively correlated with immune activity through its regulation of purine synthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Immunobiology"
DOI: 10.1016/j.imbio.2020.151931
Abstract: INTRODUCTION The purpose of this study was to examine the effects of elevated Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) on the immune response in the tumor microenvironment. METHODOLOGY HPRT expression was evaluated in cancer patients and correlated… read more here.
Keywords: negatively correlated; guanine phosphoribosyltransferase; expression; cell ... See more keywords
Availability and quality of published data on the purine content of foods, alcoholic beverages, and dietary supplements
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Food Composition and Analysis"
DOI: 10.1016/j.jfca.2019.103281
Abstract: Abstract Gout, the most common type of inflammatory arthritis and associated with elevated uric acid levels, is a global burden. “Western” dietary habits and lifestyle, and the resulting obesity epidemic, are often blamed for the… read more here.
Keywords: quality; purine; content foods; beverages dietary ... See more keywords
The effect of purine content on sensory quality of pork.
Sign Up to like & getrecommendations! Published in 2020 at "Meat science"
DOI: 10.1016/j.meatsci.2020.108346
Abstract: Although high level of purine in foods is considered a risk factor for hyperuricemia and gout, purine-rich foods continue to be popular for their delicious taste. The main objective of this study was to investigate… read more here.
Keywords: content; quality pork; sensory quality; purine ... See more keywords
Synthesis of 2-fluoro-substituted and 2,6-modified purine 2',3'-dideoxy-2',3'-difluoro-d-arabinofuranosyl nucleosides from d-xylose.
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.02.027
Abstract: A series of novel purine-modified 2',3'-dideoxy-2',3'-difluro-D-arabinonucleosides, including fluorinated analogs of fludarabine and nelarabine, have been prepared via anion glycosylation reactions of salts of 2-fluoropurine derivatives with the glycosyl bromide. A short and efficient synthetic route… read more here.
Keywords: difluoro; synthesis fluoro; difluoro arabinofuranosyl; purine ... See more keywords
Highly efficient biosynthesis of hypoxanthine in Escherichia coli and transcriptome-based analysis of the purine metabolism.
Sign Up to like & getrecommendations! Published in 2020 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.9b00396
Abstract: Nucleosides and purine analogs have multiple functions in cell physiology, food additives, and pharmaceuticals, and some are produced on a large scale using different microorganisms. However, biosynthesis of purines is still lacking. In the present… read more here.
Keywords: biosynthesis; hypoxanthine; escherichia coli; analysis ... See more keywords