Design, synthesis and evaluation of 4-aminoquinoline-purine hybrids as potential antiplasmodial agents.
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DOI: 10.1016/j.ejmech.2016.11.057
Abstract: A novel series of 4-aminoquinoline-purine hybrids were synthesized and assessed for their antiplasmodial activity against CQ-sensitive and CQ-resistant strains of P. falciparum. It was envisaged that linking of the 4-aminoquinoline pharmacophore (targeting heme-detoxification pathway of… read more here.
Keywords: design synthesis; purine hybrids; aminoquinoline purine; aminoquinoline ... See more keywords