Dual‐Specificity Tyrosine Phosphorylation–Regulated Kinase 3 Loss Activates Purine Metabolism and Promotes Hepatocellular Carcinoma Progression
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30703
Abstract: Cancer cells metabolize different energy sources to generate biomass rapidly. The purine biosynthetic pathway was recently identified as an important source of metabolic intermediates for these processes. However, very little was known about the regulatory… read more here.
Keywords: hepatocellular carcinoma; hcc; purine metabolism; metabolism ... See more keywords
Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2020.101935
Abstract: Summary Genetic variation of the 16p11.2 deletion locus containing the KCTD13 gene and of CUL3 is linked with autism. This genetic connection suggested that substrates of a CUL3-KCTD13 ubiquitin ligase may be involved in disease… read more here.
Keywords: purine metabolism; kctd13 neurons; kctd13; regulation purine ... See more keywords
Altered purine metabolism at reperfusion affects clinical outcome in lung transplantation.
Sign Up to like & getrecommendations! Published in 2022 at "Thorax"
DOI: 10.1136/thoraxjnl-2021-217498
Abstract: INTRODUCTION Lung transplantation is an established treatment for patients with end-stage lung disease. However, ischaemia reperfusion injury remains a barrier to achieving better survival outcomes. Here, we aim to investigate the metabolomic and transcriptomic profiles… read more here.
Keywords: lung; outcome; purine metabolism; reperfusion ... See more keywords
The changes in purine metabolism in gastric cancer
Sign Up to like & getrecommendations! Published in 2019 at "GASTROENTEROLOGY"
DOI: 10.22141/2308-2097.53.4.2019.182401
Abstract: Актуальность. Рак желудка (РЖ) считается актуальной проблемой онкологии, что объясняется его высокой распространенностью и смертностью вследствие него, запоздалой диагностикой заболевания, анатомо-топографическими особенностями поражаемого опухолью органа и низкой результативностью существующих методов лечения. Роль дисметаболизма пуринов в… read more here.
Keywords: purine metabolism; gastric cancer; gastroenterology; changes purine ... See more keywords
Purine metabolism regulates Vibrio splendidus persistence associated with protein aggresome formation and intracellular tetracycline efflux
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1127018
Abstract: A small subpopulation of Vibrio splendidus AJ01 that was exposed to tetracycline at 10 times the minimal inhibitory concentration (MIC) still survived, named tetracycline-induced persister cells in our previous work. However, the formation mechanisms of… read more here.
Keywords: tetracycline; purine metabolism; intracellular tetracycline; protein aggresome ... See more keywords
Integrated transcriptomic and metabolomic profiling reveals dysregulation of purine metabolism during the acute phase of spinal cord injury in rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.1066528
Abstract: Introduction Spinal cord injury (SCI) results in drastic dysregulation of microenvironmental metabolism during the acute phase, which greatly affects neural recovery. A better insight into the potential molecular pathways of metabolic dysregulation by multi-omics analysis… read more here.
Keywords: purine metabolism; dysregulation purine; metabolism; acute phase ... See more keywords
Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1089871
Abstract: Introduction Previous studies have suggested that the dysregulation of purine metabolism may be associated with autism spectrum disorder (ASD). Here, we adopted metabolomics and transcriptomics to verify and explore the underlying molecular mechanism of purine… read more here.
Keywords: purine metabolism; autism spectrum; purine; uric acid ... See more keywords
Integration of Non-Targeted Metabolomics and Targeted Quantitative Analysis to Elucidate the Synergistic Antidepressant Effect of Bupleurum Chinense DC-Paeonia Lactiflora Pall Herb Pair by Regulating Purine Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.900459
Abstract: Graphical Abstract Bupleurum chinense DC (Chaihu)-Paeonia lactiflora Pall (Baishao) is among the most accepted herb pairs in many classic antidepressant prescriptions. Our previous study has shown that the Chaihu–Baishao herb pair (CBHP) had a better… read more here.
Keywords: effect; purine metabolism; antidepressant effect; analysis ... See more keywords
The Key Role of Purine Metabolism in the Folate-Dependent Phenotype of Autism Spectrum Disorders: An In Silico Analysis
Sign Up to like & getrecommendations! Published in 2020 at "Metabolites"
DOI: 10.3390/metabo10050184
Abstract: Folate deficiency in the critical developmental period has been repeatedly associated with an increased risk of Autism spectrum disorders (ASD), but the key pathophysiological mechanism has not yet been identified. In this work, we focused… read more here.
Keywords: folate depletion; spectrum disorders; purine metabolism; depletion ... See more keywords
Transcriptome Analysis of Colletotrichum fructicola Infecting Camellia oleifera Indicates That Two Distinct Geographical Fungi Groups Have Different Destructive Proliferation Capacities Related to Purine Metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Plants"
DOI: 10.3390/plants10122672
Abstract: Anthracnose, caused by Colletotrichum spp., is a significant disease affecting oil tea (Camellia oleifera Abel.). Extensive molecular studies have demonstrated that Colletotrichum fructicola is the dominant pathogen of oil tea anthracnose in China. This study… read more here.
Keywords: metabolism; purine metabolism; oil tea; fructicola ... See more keywords