Hepatic xanthine oxidase activity and purine nucleosides levels as physiological mediators to analyze a subcutaneous treatment with (PhSe)2 in mice infected by Toxoplasma gondii.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.01.022
Abstract: The aim of this study was to evaluate the levels of purine nucleosides and xanthine oxidase (XO) activity in the liver of mice chronically infected by Toxoplasma gondii and treated with diphenyl diselenide (PhSe)2. For… read more here.
Keywords: purine nucleosides; treatment; group; phse ... See more keywords
Regioselective C6-H Hydroxyalkylation of Purines and Purine Nucleosides via α-C-H Functionalization of Alcohols at Room Temperature.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01680
Abstract: The highly regioselective C6-H hydroxylalkylation of purines and purine nucleosides within 10 min via the α-C(sp3)-H functionalization of alcohols at room temperature is reported here for the first time. The reaction tolerated various functional groups,… read more here.
Keywords: purine nucleosides; purines purine; functionalization alcohols; room temperature ... See more keywords
Lactobacillus gasseri PA-3, but not L. gasseri OLL2996, reduces the absorption of purine nucleosides in rats
Sign Up to like & getrecommendations! Published in 2018 at "Nucleosides, Nucleotides and Nucleic Acids"
DOI: 10.1080/15257770.2018.1469760
Abstract: ABSTRACT Lactobacillus gasseri PA-3 (PA-3) is a bacterial strain with a strong ability to degrade purine nucleosides. We previously showed that PA-3 incorporates purines in vitro and that oral administration of PA-3 and purines to… read more here.
Keywords: absorption; bacterial strain; lactobacillus gasseri; purine nucleosides ... See more keywords
Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba3688
Abstract: Metabolic analysis of ADA2-deficient cells shows that extracellular purine nucleosides trigger cellular innate immunity. Mechanisms linking immune sensing of DNA danger signals in the extracellular environment to innate pathways in the cytosol are poorly understood.… read more here.
Keywords: purine nucleosides; ifn response; dino; extracellular purine ... See more keywords
Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics
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DOI: 10.1128/mbio.02478-22
Abstract: The clinical burden of infections caused by antimicrobial resistant (AMR) pathogens is a leading threat to public health. Maintaining the effectiveness of existing antimicrobial drugs or finding ways to reintroduce drugs to which resistance is… read more here.
Keywords: mrsa lactam; purine nucleosides; lactam resistance; resistance ... See more keywords