Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae
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DOI: 10.1007/s00294-020-01101-y
Abstract: Because metabolism is a complex balanced process involving multiple enzymes, understanding how organisms compensate for transient or permanent metabolic imbalance is a challenging task that can be more easily achieved in simpler unicellular organisms. The… read more here.
Keywords: imbalance; purine nucleotide; investigation purine; nucleotide imbalance ... See more keywords
Horizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis
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DOI: 10.1111/mmi.14393
Abstract: A microbe’s ecological niche and biotechnological utility are determined by its specific set of co‐evolved metabolic pathways. The acquisition of new pathways, through horizontal gene transfer or genetic engineering, can have unpredictable consequences. Here we… read more here.
Keywords: catabolism; purine nucleotide; coumarate catabolism; nucleotide biosynthesis ... See more keywords
Structural basis of purine nucleotide inhibition of human uncoupling protein 1.
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DOI: 10.1126/sciadv.adh4251
Abstract: Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its specialized ability to burn calories as heat for thermoregulation. When activated by fatty acids, UCP1 catalyzes the leak of protons across the mitochondrial… read more here.
Keywords: uncoupling protein; purine; structural basis; basis purine ... See more keywords
Abstract MP121: Deleting the 2-oxoglutarate- and Iron-dependent Prolyl Hydroxylase Ogfod1 Alters Purine Nucleotide Regulation and is Cardioprotective
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DOI: 10.1161/res.127.suppl_1.mp121
Abstract: Prolyl hydroxylation is a post-translational modification that regulates protein stability, turnover, and activity. The proteins that catalyze prolyl hydroxylation belong to the 2-oxoglutarate- and iron-dependent oxygenase family of enzymes. A newly-described member of this family… read more here.
Keywords: ogfod1; purine nucleotide; iron dependent; mice ... See more keywords