TLR8 is activated by 5'-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway.
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DOI: 10.1016/j.celrep.2022.110691
Abstract: The innate immune recognition of the malaria-causing pathogen Plasmodium falciparum (P. falciparum) is not fully explored. Here, we identify the nucleoside 5'-methylthioinosine (MTI), a Plasmodium-specific intermediate of the purine salvage pathway, as a pathogen-derived Toll-like receptor… read more here.
Keywords: plasmodium; intermediate purine; purine salvage; salvage pathway ... See more keywords
A Functional Analysis of the Purine Salvage Pathway in Acetobacter fabarum
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00041-22
Abstract: Acetobacter are commonly found in the gut microbiota of fruit flies, including Drosophila melanogaster. We evaluated the function of purine salvage genes in Acetobacter fabarum to test the hypothesis that this bacterium can utilize host… read more here.
Keywords: acetobacter fabarum; host; purine salvage; utilize host ... See more keywords