Purinergic P2X7 Receptor: A Therapeutic Target in Amyotrophic Lateral Sclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00133
Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by upper and lower motor neuron loss. The pathomechanisms of ALS are still poorly understood with current hypotheses involving genetic mutations, excitotoxicity, and reactive oxygen… read more here.
Keywords: p2x7 receptor; lateral sclerosis; purinergic p2x7; amyotrophic lateral ... See more keywords
Recent advances in the development of antidepressants targeting the purinergic P2X7 receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220629141418
Abstract: The purinergic P2X7 receptor (P2X7R) is an adenosine triphosphate (ATP)-gated cation channel protein. Although extracellular ATP (eATP) is maintained at the nanomolar concentration range under normal conditions, it is elevated to micromolar levels in response… read more here.
Keywords: p2x7 receptor; development; purinergic p2x7; p2x7r ... See more keywords
Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.613449
Abstract: The cardiovascular toxicity of Abacavir is related to its purinergic structure. Purinergic P2X7-receptors (P2X7R), characterized by activation by high concentrations of ATP and with high plasticity, seem implicated. We appraise the nature of the interplay… read more here.
Keywords: purinergic p2x7; atp; cardiovascular toxicity; cbv ... See more keywords
The Role of Purinergic P2X7 Receptor in Inflammation and Cancer: Novel Molecular Insights and Clinical Applications
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14051116
Abstract: Simple Summary The purinergic P2X7 receptor (P2X7R) is a cell membrane protein whose activation has been related to a variety of cellular processes, while its dysregulation has been linked to inflammation and cancer. ATP plays… read more here.
Keywords: role; inflammation cancer; purinergic p2x7; p2x7r ... See more keywords
The Purinergic P2X7 Receptor-NLRP3 Inflammasome Pathway: A New Target in Alcoholic Liver Disease?
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22042139
Abstract: The World Health Organization has estimated that approximately 3 million deaths are attributable to alcohol consumption each year. Alcohol consumption is notably associated with the development and/or progression of many non-communicable inflammatory diseases—particularly in the… read more here.
Keywords: purinergic p2x7; alcoholic liver; nlrp3 inflammasome; liver disease ... See more keywords