A purinergic P2Y6 receptor agonist prodrug modulates airway inflammation, remodeling, and hyperreactivity in a mouse model of asthma
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DOI: 10.2147/jaa.s151849
Abstract: Background Purinergic receptors control cell proliferation, apoptosis, migration, inflammation, and cytokine secretion. Increased expression of specific purinergic receptors is reported in asthma. The role of purinergic P2Y6 receptors (P2Y6R) in asthma is controversial. Hypothesis P2Y6R… read more here.
Keywords: purinergic p2y6; inflammation; agonist prodrug; gc021109 ... See more keywords
Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis
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DOI: 10.3390/ijms24043800
Abstract: Nonalcoholic steatohepatitis (NASH) is a disease that progresses from nonalcoholic fatty liver (NAFL) and which is characterized by inflammation and fibrosis. The purinergic P2Y6 receptor (P2Y6R) is a pro-inflammatory Gq/G12 family protein-coupled receptor and reportedly… read more here.
Keywords: inflammation; purinergic p2y6; liver injury; p2y6 receptor ... See more keywords