The P2X7 purinergic receptor in intervertebral disc degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30611
Abstract: Mechanisms involved in the development of intervertebral disc (IVD) degeneration are only partially known, thus making the implementation of effective therapies very difficult. In this study, we investigated P2X7 purinergic receptor (P2X7R), NLRP3 inflammasome, and… read more here.
Keywords: p2x7r nlrp3; p2x7r; intervertebral disc; purinergic receptor ... See more keywords
Characterization of purinergic receptor 2 signaling in podocytes from diabetic kidneys
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102528
Abstract: Summary Growing evidence suggests that renal purinergic signaling undergoes significant remodeling during pathophysiological conditions such as diabetes. This study examined the renal P2 receptor profile and ATP-mediated calcium response from podocytes in glomeruli from kidneys… read more here.
Keywords: receptor; intracellular calcium; purinergic receptor; atp mediated ... See more keywords
Actin-mediated Microglial Chemotaxis via G-Protein Coupled Purinergic Receptor in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.09.024
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease mainly associated with aging, oxidative stress and genetic mutations. There are two pathological proteins involved in AD; Amyloid-β peptide and microtubule-associated protein Tau (MAPT). The β- and γ-secretase… read more here.
Keywords: protein; alzheimer disease; disease; purinergic receptor ... See more keywords
The role of agonist-induced activation and inhibition for the regulation of purinergic receptor expression in human platelets.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2018.05.029
Abstract: INTRODUCTION Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. The inhibition of P2Y12 is used pharmacologically to suppress aggregation underlining the physiological significance… read more here.
Keywords: receptor expression; inhibition; expression; purinergic receptor ... See more keywords
The purinergic receptor antagonist oxidized adenosine triphosphate suppresses immune-mediated corneal allograft rejection
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44973-y
Abstract: Adenosine triphosphate (ATP) is released into the extracellular environment during transplantation, and acts via purinergic receptors to amplify the alloimmune response. Here, using a well-established murine model of allogeneic corneal transplantation, we investigated the immunomodulatory… read more here.
Keywords: receptor antagonist; antagonist oxidized; adenosine triphosphate; purinergic receptor ... See more keywords
Purinergic receptor mediated calcium signalling in urothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52531-9
Abstract: Non-neuronal ATP released from the urothelium in response to bladder stretch is a key modulator of bladder mechanosensation. Whilst non-neuronal ATP acts on the underlying bladder afferent nerves to facilitate sensation, there is also the… read more here.
Keywords: atp; urothelial cells; purinergic receptor; calcium ... See more keywords
Deficiency of the Purinergic Receptor 2X7 Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/8962458
Abstract: Molecular mechanisms driving transition from simple steatosis to nonalcoholic steatohepatitis (NASH), a critical step in the progression of nonalcoholic fatty liver disease (NAFLD) to cirrhosis, are poorly defined. This study aimed at investigating the role… read more here.
Keywords: fat diet; nonalcoholic steatohepatitis; purinergic receptor; nlrp3 inflammasome ... See more keywords
Inhibition of P2X7 Purinergic Receptor Ameliorates Cardiac Fibrosis by Suppressing NLRP3/IL-1β Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/7956274
Abstract: P2X7 purinergic receptor (P2X7R) has been implicated in several cardiovascular diseases. However, whether it regulates cardiac fibrosis remains elusive. Herein, its involvement in the development of cardiac fibrosis was examined using a transverse aortic constriction… read more here.
Keywords: fibrosis; cardiac fibrosis; purinergic receptor; p2x7 purinergic ... See more keywords
New (re)Purpose for an old drug: purinergic receptor blockade may extinguish the COVID-19 thrombo-inflammatory firestorm.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.140971
Abstract: Purinergic modulators, such as dipyridamole, target multiple pathways that have been implicated in COVID-19 pathogenesis, and thus the therapeutic benefit of these should be explored. read more here.
Keywords: drug purinergic; old drug; receptor blockade; purpose old ... See more keywords
Targeting Purinergic Receptor P2RX1 Modulates Intestinal Microbiota and Alleviates Inflammation in Colitis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.696766
Abstract: Inflammatory bowel disease (IBD) remains one of the most prevalent gastrointestinal diseases worldwide. Purinergic signaling has emerged as a promising therapeutic target of inflammation-associated diseases. However, little is known about the specific roles of purinergic… read more here.
Keywords: p2rx1; inflammation; receptor p2rx1; colitis ... See more keywords
P2X7 purinergic receptor: A potential target in heart diseases (Review).
Sign Up to like & getrecommendations! Published in 2023 at "Molecular medicine reports"
DOI: 10.3892/mmr.2023.12961
Abstract: The P2X7 purinergic receptor (P2X7R) is a non‑selective cation channel activated by high levels of adenosine triphosphate that are commonly present in serious conditions. Activation of this purinergic receptor is closely related to the development… read more here.
Keywords: purinergic receptor; p2x7 purinergic; heart diseases; development ... See more keywords