Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Human Mutation"
DOI: 10.1002/humu.23218
Abstract: Genetic variants in the purinergic receptors P2RX4 and P2RX7 have been shown to affect susceptibility to multiple sclerosis (MS). In this study, we set out to evaluate whether rare coding variants of major effect could… read more here.
Keywords: receptors p2rx4; p2rx7 familial; multiple sclerosis; purinergic receptors ... See more keywords
Purinergic receptors modulators: An emerging pharmacological tool for disease management
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21888
Abstract: Purinergic signaling is mediated through extracellular nucleotides (adenosine 5′‐triphosphate, uridine‐5'‐triphosphate, adenosine diphosphate, uridine‐5'‐diphosphate, and adenosine) that serve as signaling molecules. In the early 1990s, purines and pyrimidine receptors were cloned and characterized drawing the attention… read more here.
Keywords: pharmacological tool; purinergic receptors; emerging pharmacological; modulators emerging ... See more keywords
Purinergic Receptors Crosstalk with CCR5 to Amplify Ca2+ Signaling
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-01002-1
Abstract: Many G protein-coupled receptors (GPCRs) signal through more than one subtype of heterotrimeric G proteins. For example, the C–C chemokine receptor type 5 (CCR5), which serves as a co-receptor to facilitate cellular entry of human… read more here.
Keywords: protein; amplify ca2; ccr5 amplify; receptors crosstalk ... See more keywords
Targeting purinergic receptors to attenuate inflammation of dry eye.
Sign Up to like & getrecommendations! Published in 2022 at "Purinergic signalling"
DOI: 10.1007/s11302-022-09851-9
Abstract: Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic A1, A2A, A3, P2X4, P2X7, P2Y1, P2Y2, and P2Y4 receptors play… read more here.
Keywords: dry eye; targeting purinergic; pro inflammatory; purinergic receptors ... See more keywords
Characterizing purinergic receptors in the gastrointestinal epithelium and immune cells
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731809
Abstract: Background: Extracellular release of nucleotides (e.g., ATP, ADP, UTP, UDP) are well established as potent intercellular signaling molecules during homeostasis but are also released from cells during pathogenic microbial infection and tissue injury to serve… read more here.
Keywords: purinergic receptors; expression; physiology; purinergic signaling ... See more keywords
Purinergic signaling in the male reproductive tract
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1049511
Abstract: Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions. Extracellular nucleotides activate several types of plasma membrane purinergic… read more here.
Keywords: reproductive tract; purinergic receptors; purinergic signaling; male reproductive ... See more keywords
Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.947885
Abstract: ATP and other nucleoside phosphates have specific receptors named purinergic receptors. Purinergic receptors and ectonucleotidases regulate various signaling pathways that play a role in physiological and pathological processes. Extracellular ATP in the tumor microenvironment (TME)… read more here.
Keywords: cancer; purinergic receptors; metabolic reprogramming; resistance ... See more keywords
The adenosinergic machinery in cancer: In-tandem insights from basic mechanisms to therapy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1111369
Abstract: Extracellular adenosine (eADO) signaling has emerged as an increasingly important regulator of immune responses, including tumor immunity. eADO is mainly produced from extracellular ATP (eATP) hydrolysis. eATP is rapidly accumulated in the extracellular space following… read more here.
Keywords: purinergic receptors; adenosinergic machinery; machinery cancer; eado ... See more keywords
Role of Adenosine and Purinergic Receptors in Myocardial Infarction: Focus on Different Signal Transduction Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9020204
Abstract: Myocardial infarction (MI) is a dramatic event often caused by atherosclerotic plaque erosion or rupture and subsequent thrombotic occlusion of a coronary vessel. The low supply of oxygen and nutrients in the infarcted area may… read more here.
Keywords: myocardial infarction; catenin pathway; role; purinergic receptors ... See more keywords
The Role of Microglial Purinergic Receptors in Pain Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27061919
Abstract: Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal and… read more here.
Keywords: microglial purinergic; role; purinergic receptors; receptors pain ... See more keywords