Blocking TNFα‐driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23519
Abstract: Epilepsy is characterized by unpredictable recurrent seizures resulting from abnormal neuronal excitability. Increasing evidence indicates that aberrant astrocyte signaling to neurons plays an important role in driving the network hyperexcitability, but the underlying mechanism that… read more here.
Keywords: epilepsy; glutamate release; synaptic activity; activity ... See more keywords
Knockout and Knock-in Mouse Models to Study Purinergic Signaling.
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DOI: 10.1007/978-1-4939-9717-6_2
Abstract: Purinergic signaling involves extracellular purines and pyrimidines acting upon specific cell surface purinoceptors classified into the P1, P2X, and P2Y families for nucleosides and nucleotides. This widespread signaling mechanism is active in all major tissues… read more here.
Keywords: purinergic signaling; knockout knock; mouse models; mouse ... See more keywords
Purinergic Signaling in Glioma Progression.
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DOI: 10.1007/978-3-030-30651-9_5
Abstract: Among the pathological alterations that give tumor cells invasive potential, purinergic signaling is emerging as an important component. Studies performed in in vitro, in vivo and ex vivo glioma models indicate that alterations in the purinergic signaling… read more here.
Keywords: glioma progression; purinergic; purinergic signaling; tumor ... See more keywords
Targeting Purinergic Signaling and Cell Therapy in Cardiovascular and Neurodegenerative Diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-31206-0_14
Abstract: Extracellular purines exert several functions in physiological and pathophysiological mechanisms. ATP acts through P2 receptors as a neurotransmitter and neuromodulator and modulates heart contractility, while adenosine participates in neurotransmission, blood pressure, and many other mechanisms.… read more here.
Keywords: cardiovascular neurodegenerative; neurodegenerative diseases; therapy; stem ... See more keywords
Caffeine modulates brain purinergic signaling in Nile tilapia (Oreochromis niloticus) under hypoxia conditions: improvement of immune and inflammatory responses
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DOI: 10.1007/s10695-018-0592-z
Abstract: Purinergic signaling is linked to neurodegenerative and proinflammatory damage during pathological conditions such as hypoxia, but involvement of this pathway in brain damage in fish exposed to environmental hypoxia remains unknown, and we propose dietary… read more here.
Keywords: group group; caffeine; group; inflammatory ... See more keywords
Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling—an update
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DOI: 10.1007/s11302-020-09698-y
Abstract: Bone marrow (BM) as an active hematopoietic organ is highly sensitive to changes in body microenvironments and responds to external physical stimuli from the surrounding environment. In particular, BM tissue responds to several cues related… read more here.
Keywords: immunity; mobilization; hematopoietic stem; innate immunity ... See more keywords
Purinergic signaling in tanycytes and its contribution to nutritional sensing.
Sign Up to like & getrecommendations! Published in 2021 at "Purinergic signalling"
DOI: 10.1007/s11302-021-09791-w
Abstract: Tanycytes are hypothalamic radial glial-like cells with an important role in the regulation of neuroendocrine axes and energy homeostasis. These cells have been implicated in glucose, amino acids, and fatty acid sensing in the hypothalamus… read more here.
Keywords: signaling tanycytes; contribution nutritional; role; purinergic signaling ... See more keywords
Optical control of purinergic signaling
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DOI: 10.1007/s11302-021-09799-2
Abstract: Purinergic signaling plays a pivotal role in physiological processes and pathological conditions. Over the past decades, conventional pharmacological, biochemical, and molecular biology techniques have been utilized to investigate purinergic signaling cascades. However, none of them… read more here.
Keywords: purinergic; control purinergic; biology; optical control ... See more keywords
Purinergic signaling in thyroid disease.
Sign Up to like & getrecommendations! Published in 2022 at "Purinergic signalling"
DOI: 10.1007/s11302-022-09858-2
Abstract: It is known that thyroid hormones play pivotal roles in a wide variety of pathological and physiological events. Thyroid diseases, mainly including hyperthyroidism, hypothyroidism, and thyroid cancer, are highly prevalent worldwide health problems and frequently… read more here.
Keywords: signaling thyroid; thyroid cancer; thyroid diseases; purinergic signaling ... See more keywords
Involvement of purinergic signaling in the Amazon fish Pterygoplichthys pardalis subjected to handling stress: Relationship with immune response
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DOI: 10.1016/j.aquaculture.2019.734481
Abstract: Abstract Stress has a considerable impact on the welfare and productivity of fish, and stress caused by transport and handling can result in mortality rates of up to 73%. Cortisol is the major corticosteroid produced… read more here.
Keywords: involvement purinergic; handling stress; response; stress ... See more keywords
Nanobodies as probes to investigate purinergic signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114394
Abstract: Nanobodies (VHHs) are the single variable immunoglobulin domains of heavy chain antibodies (hcAbs) that naturally occur in alpacas and other camelids. The two variable domains of conventional antibodies typically interact via a hydrophobic interface. In… read more here.
Keywords: nanobodies probes; purinergic; investigate purinergic; pharmacology ... See more keywords