CDR2 and CDR2L Yo Antigens in Paraneoplastic Cerebellar Degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25790
Abstract: We read with great interest the article by the group of Kråkenes et al, “CDR2L Is the Major Antibody Target in Paraneoplastic Cerebellar Degeneration.” We have previously demonstrated, as has that same group, that anti-Yo… read more here.
Keywords: paraneoplastic cerebellar; cerebellar degeneration; antibody; purkinje ... See more keywords
Cdk5 activity is required for Purkinje cell dendritic growth in cell‐autonomous and non‐cell‐autonomous manners
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22507
Abstract: Cyclin‐dependent kinase 5 (Cdk5) is recognized as a unique member among other Cdks due to its versatile roles in many biochemical processes in the nervous system. The proper development of neuronal dendrites is required for… read more here.
Keywords: purkinje cell; cell autonomous; purkinje; cdk5 activity ... See more keywords
Electrophysiological features of repetitive focal Purkinje ventricular arrhythmias originating from the proximal cardiac conduction system
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Arrhythmia"
DOI: 10.1002/joa3.12787
Abstract: Focal Purkinje ventricular arrhythmias (VAs) might originate from the vicinity of the proximal portion of the cardiac conducting system. This study aimed to clarify the features associated with focal Purkinje VAs originating from the proximal… read more here.
Keywords: system; originating proximal; purkinje ventricular; purkinje ... See more keywords
Cultivation of Purified Primary Purkinje Cells from Rat Cerebella
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0606-5
Abstract: Primary neurons are difficult to cultivate because they are often part of a complex tissue, and synaptically connected to numerous other cell types. These circumstances often prevent us from unveiling molecular and metabolic mechanisms of… read more here.
Keywords: cultivation purified; protocol; rat cerebella; purkinje ... See more keywords
Purkinje physiology and pathophysiology
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Interventional Cardiac Electrophysiology"
DOI: 10.1007/s10840-018-0414-3
Abstract: There has always been an appreciation of the role of Purkinje fibers in the fast conduction of the normal cardiac impulse. Here, we briefly update our knowledge of this important set of cardiac cells. We… read more here.
Keywords: purkinje physiology; strand; physiology pathophysiology; physiology ... See more keywords
Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cells differentiation.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2022.03.010
Abstract: Pontocerebellar hypoplasias (PCHs) are congenital disorders characterized by hypoplasia or early atrophy of the cerebellum and brainstem, leading to a very limited motor and cognitive development. Although over 20 genes have been shown to be… read more here.
Keywords: purkinje; hypoplasia; purkinje cells; brainstem dysfunction ... See more keywords
Use of a high-density mapping catheter for Purkinje-related ventricular tachycardia in a patient with a previous history of anterior myocardial infarction
Sign Up to like & getrecommendations! Published in 2021 at "HeartRhythm Case Reports"
DOI: 10.1016/j.hrcr.2021.01.007
Abstract: Catheter ablation targets the mid-to-late diastolic potential (P1), which is a sharp and high-frequency potential preceding the Purkinje potential (P2). However, the P1 potentials are only observed in less than one-third of all cases. Moreover,… read more here.
Keywords: catheter; use high; high density; density mapping ... See more keywords
Intrinsic memory of temporal intervals in cerebellar Purkinje cells
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2019.107103
Abstract: The general consensus for learning and memory, including in the cerebellum, is that modification of synaptic strength via long-term potentiation (LTP) or long-term depression (LTD) are the primary mechanisms for the formation of memories. Recent… read more here.
Keywords: purkinje; purkinje cell; synaptic strength; cerebellar purkinje ... See more keywords
Purkinje cell number-correlated cerebrocerebellar circuit anomaly in the valproate model of autism
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45667-1
Abstract: While cerebellar alterations may play a crucial role in the development of core autism spectrum disorder (ASD) symptoms, their pathophysiology on the function of cerebrocerebellar circuit loops is largely unknown. We combined multimodal MRI (9.4 T)… read more here.
Keywords: purkinje; cell number; purkinje cell; number ... See more keywords
Kir3 channel blockade in the cerebellar cortex suppresses performance of classically conditioned Purkinje cell responses
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72581-8
Abstract: In the eyeblink conditioning paradigm, cerebellar Purkinje cells learn to respond to the conditional stimulus with an adaptively timed pause in its spontaneous firing. Evidence suggests that the pause is elicited by glutamate released from… read more here.
Keywords: conditioned purkinje; cerebellar cortex; purkinje cell; purkinje ... See more keywords
Time and tide of cerebellar synchrony
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204155119
Abstract: Just over half a century ago Bell and Grimm (1) were the first to record simultaneously from multiple Purkinje cells, revealing that different Purkinje cells can fire in synchrony within the same few milliseconds. This… read more here.
Keywords: movement; fiber; synchrony; purkinje ... See more keywords