Spatial rearrangement of Purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24250
Abstract: Transversely oriented lobules and longitudinally arrayed stripes of Purkinje cell subsets subdivide the cerebellar cortex into multiple compartments that are involved in diverse functions. In the mammalian cerebellum, anterior, and posterior lobules, which are involved… read more here.
Keywords: subsets forms; purkinje cell; cell subsets; cerebellum ... See more keywords
Cdk5 activity is required for Purkinje cell dendritic growth in cell‐autonomous and non‐cell‐autonomous manners
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22507
Abstract: Cyclin‐dependent kinase 5 (Cdk5) is recognized as a unique member among other Cdks due to its versatile roles in many biochemical processes in the nervous system. The proper development of neuronal dendrites is required for… read more here.
Keywords: purkinje cell; cell autonomous; purkinje; cdk5 activity ... See more keywords
Stochastic reaction-diffusion modeling of calcium dynamics in 3D-dendritic spines of Purkinje Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.03.027
Abstract: Calcium (Ca2+) is a second messenger assumed to control changes in synaptic strength in the form of both long-term depression (LTD) and long-term potentiation (LTP) at Purkinje cell dendritic spine synapses via inositol trisphosphate (IP3)… read more here.
Keywords: ca2 transients; purkinje cell; reaction diffusion; ca2 ... See more keywords
Spinocerebellar ataxia: miRNAs expose biological pathways underlying pervasive Purkinje cell degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.08.003
Abstract: Recent work has demonstrated the importance of miRNAs in the pathogenesis of various brain disorders including the neurodegenerative disorder spinocerebellar ataxia (SCA). This review focuses on the role of miRNAs in the shared pathogenesis of… read more here.
Keywords: spinocerebellar ataxia; biological pathways; pervasive purkinje; purkinje cell ... See more keywords
ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135337
Abstract: Spinocerebellar ataxia type17 (SCA17) is an autosomal dominant neurodegenerative disease caused by CAG expansion in the gene encoding the TATA-binding protein (TBP). The neurological features of SCA17 are Purkinje cell loss and gliosis. We have… read more here.
Keywords: erk activation; erk; purkinje cell; mice ... See more keywords
Activation CRF-R2 augments cerebellar climbing fiber-Purkinje cell synaptic transmission via presynaptic PKA pathway in mice
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136584
Abstract: Corticotropin releasing factor (CRF) type 2 receptor (CRF-R2) is present in climbing fiber (CF) afferents, which involves in modulating the CF-Purkinje cell (PC) synaptic transmission in cerebellar cortex. However, the role of CRF-R2 in regulating… read more here.
Keywords: pka; crf; purkinje cell; synaptic transmission ... See more keywords
Conversion of Graded Presynaptic Climbing Fiber Activity into Graded Postsynaptic Ca2+ Signals by Purkinje Cell Dendrites
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.03.010
Abstract: The brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts… read more here.
Keywords: cell dendrites; ca2 signals; purkinje cell; activity ... See more keywords
Intrinsic memory of temporal intervals in cerebellar Purkinje cells
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2019.107103
Abstract: The general consensus for learning and memory, including in the cerebellum, is that modification of synaptic strength via long-term potentiation (LTP) or long-term depression (LTD) are the primary mechanisms for the formation of memories. Recent… read more here.
Keywords: purkinje; purkinje cell; synaptic strength; cerebellar purkinje ... See more keywords
Purkinje cell number-correlated cerebrocerebellar circuit anomaly in the valproate model of autism
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45667-1
Abstract: While cerebellar alterations may play a crucial role in the development of core autism spectrum disorder (ASD) symptoms, their pathophysiology on the function of cerebrocerebellar circuit loops is largely unknown. We combined multimodal MRI (9.4 T)… read more here.
Keywords: purkinje; cell number; purkinje cell; number ... See more keywords
Kir3 channel blockade in the cerebellar cortex suppresses performance of classically conditioned Purkinje cell responses
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72581-8
Abstract: In the eyeblink conditioning paradigm, cerebellar Purkinje cells learn to respond to the conditional stimulus with an adaptively timed pause in its spontaneous firing. Evidence suggests that the pause is elicited by glutamate released from… read more here.
Keywords: conditioned purkinje; cerebellar cortex; purkinje cell; purkinje ... See more keywords
Reply to Piochon et al.: NMDARs in Purkinje cells are not involved in parallel fiber–Purkinje cell synaptic plasticity or motor learning
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120480119
Abstract: In our study we presented functional and immuno-histochemical evidence for the presence of presynaptic N -methyl-D-aspartate receptors (pre-NMDARs) at parallel fi ber – Purkinje cell (PF-PC) synapses in the adult cerebellum. As in young rodents,… read more here.
Keywords: cell; piochon nmdars; purkinje cell; synaptic plasticity ... See more keywords