Diversity of cellular physiology and morphology of Purkinje cells in the adult zebrafish cerebellum
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25435
Abstract: This study was designed to explore the functional circuitry of the adult zebrafish cerebellum, focusing on its Purkinje cells and using whole‐cell patch recordings and single cell labeling in slice preparations. Following physiological characterizations, the… read more here.
Keywords: cell; molecular layer; physiology; purkinje cells ... See more keywords
Cdk5 activity is required for Purkinje cell dendritic growth in cell‐autonomous and non‐cell‐autonomous manners
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22507
Abstract: Cyclin‐dependent kinase 5 (Cdk5) is recognized as a unique member among other Cdks due to its versatile roles in many biochemical processes in the nervous system. The proper development of neuronal dendrites is required for… read more here.
Keywords: purkinje cell; cell autonomous; purkinje; cdk5 activity ... See more keywords
Maternal marginal iodine deficiency limits dendritic growth of cerebellar purkinje cells in rat offspring by NF‐κB signaling and MAP1B
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22320
Abstract: Iodine deficiency (ID) during early pregnancy had an adverse effect on children's psychomotor and motor function. It is worth noting that maternal marginal ID tends to be a common public health problem. Whether marginal ID… read more here.
Keywords: maternal marginal; dendritic growth; iodine deficiency; cerebellar purkinje ... See more keywords
Aberrant connections between climbing fibres and Purkinje cells induce alterations in the timing of an instrumental response in the rat
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Brain Research"
DOI: 10.1007/s00221-017-5014-4
Abstract: Cerebellar participation in timing and sensory-motor sequences has been supported by several experimental and clinical studies. A relevant role of the cerebellum in timing of conditioned responses in the range of milliseconds has been demonstrated,… read more here.
Keywords: fibres purkinje; response; climbing fibres; cerebellum ... See more keywords
Cultivation of Purified Primary Purkinje Cells from Rat Cerebella
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0606-5
Abstract: Primary neurons are difficult to cultivate because they are often part of a complex tissue, and synaptically connected to numerous other cell types. These circumstances often prevent us from unveiling molecular and metabolic mechanisms of… read more here.
Keywords: cultivation purified; protocol; rat cerebella; purkinje ... See more keywords
Subchronic Administration of High-Dose Sodium Fluoride Causes Deficits in Cerebellar Purkinje Cells But Not Motor Coordination of Rats
Sign Up to like & getrecommendations! Published in 2018 at "Biological Trace Element Research"
DOI: 10.1007/s12011-018-1420-0
Abstract: Fluoride is frequently added to drinking water supplies, various food products, toothpaste, and mouth rinses to prevent tooth damage. However, at high concentrations, fluoride can cause fluorosis and damage to the brain tissue due to… read more here.
Keywords: sodium fluoride; purkinje cells; motor coordination;
Myocyte Enhancer Factor 2c Regulates Dendritic Complexity and Connectivity of Cerebellar Purkinje Cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1363-7
Abstract: Mef2c haploinsufficiency is implicated in behavioral deficits related to autism, schizophrenia, and intellectual disability. Although perturbations in the cerebellum, notably Purkinje cells, have been linked to these neurological disorders, the underlying mechanisms remain poorly understood.… read more here.
Keywords: mef2c expression; purkinje cells; mef2c; cerebellar purkinje ... See more keywords
Immunoreactivity pattern of calretinin in the developing human cerebellar cortex.
Sign Up to like & getrecommendations! Published in 2017 at "Acta histochemica"
DOI: 10.1016/j.acthis.2017.01.005
Abstract: The immunohistochemical expression of the calcium-binding protein calretinin during human cerebellar development has been investigated in this study. Human cerebellum samples, obtained from 7 fetuses and newborns ranging from 11 to 38 weeks of gestation,… read more here.
Keywords: cerebellar interneurons; human cerebellar; calretinin; immunoreactivity ... See more keywords
Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cells differentiation.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2022.03.010
Abstract: Pontocerebellar hypoplasias (PCHs) are congenital disorders characterized by hypoplasia or early atrophy of the cerebellum and brainstem, leading to a very limited motor and cognitive development. Although over 20 genes have been shown to be… read more here.
Keywords: purkinje; hypoplasia; purkinje cells; brainstem dysfunction ... See more keywords
Purkinje cell-specific deletion of CREB worsens alcohol-induced cerebellar neuronal losses and motor deficits.
Sign Up to like & getrecommendations! Published in 2022 at "Alcohol"
DOI: 10.1016/j.alcohol.2022.02.005
Abstract: INTRODUCTION Exposure to alcohol during pregnancy can kill developing fetal neurons and lead to FASD in the offspring. However, not all fetuses are equally vulnerable to alcohol toxicity. These differences in vulnerability among individuals are… read more here.
Keywords: alcohol; cell; creb; purkinje cells ... See more keywords
Loss of CRMP1 and CRMP2 results in migration defects of Purkinje cells in the X lobule of the mouse cerebellum
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research"
DOI: 10.1016/j.brainres.2022.147846
Abstract: The three-layered structure of the mammalian cerebellar cortex is generated through the coordinated migration of cerebellar neurons. Purkinje cells migrate and form a three- to four-cell-thick aggregate below the external granule cell layer during the… read more here.
Keywords: purkinje cells; crmp1 crmp2; migration; cells lobule ... See more keywords