Potassium channel dysfunction underlies Purkinje neuron spiking abnormalities in spinocerebellar ataxia type 2
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DOI: 10.1093/hmg/ddx281
Abstract: &NA; Alterations in Purkinje neuron firing often accompany ataxia, but the molecular basis for these changes is poorly understood. In a mouse model of spinocerebellar ataxia type 2 (SCA2), a progressive reduction in Purkinje neuron… read more here.
Keywords: ataxia type; spinocerebellar ataxia; potassium; repetitive spiking ... See more keywords
Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia
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DOI: 10.1093/hmg/ddy050
Abstract: Among the many types of neurons expressing protein kinase C (PKC) enzymes, cerebellar Purkinje neurons are particularly reliant on appropriate PKC activity for maintaining homeostasis. The importance of PKC enzymes in Purkinje neuron health is… read more here.
Keywords: cerebellar ataxia; purkinje neuron; protein kinase; pkc ... See more keywords