LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "puromycin aminonucleoside" as a keyword



Photo by mbrunacr from unsplash

In glomerular cells of puromycin aminonucleoside nephrosis rats both phosphorylated and total STAT3 levels increased during proteinuria.

Sign Up to like & get
recommendations! Published in 2018 at "Acta histochemica"

DOI: 10.1016/j.acthis.2018.07.005

Abstract: Recent studies showed that JAK/STAT pathway plays role in glomerular damages. The fact that STAT3 could be activated also by oxidative stress make Puromycin Aminonucleoside (PAN) Nephrosis model very appropriate for examination of STAT3 expression… read more here.

Keywords: puromycin aminonucleoside; phosphorylated total; stat3 levels; total stat3 ... See more keywords
Photo by aridley88 from unsplash

Nicorandil protects podocytes via modulation of antioxidative capacity in acute puromycin aminonucleoside-induced nephrosis in rats

Sign Up to like & get
recommendations! Published in 2022 at "American Journal of Physiology - Renal Physiology"

DOI: 10.1152/ajprenal.00144.2022

Abstract: Nephrotic syndrome, characterized by proteinuria and hypoalbuminemia, results from the dysregulation of glomerular podocytes and is a significant cause of end-stage kidney disease. Patients with idiopathic nephrotic syndrome are generally treated with immunosuppressive agents; however,… read more here.

Keywords: pan rats; pan; puromycin aminonucleoside; physiology ... See more keywords
Photo by vedranafilipovic from unsplash

Calcitriol Prevents Cardiovascular Repercussions in Puromycin Aminonucleoside-Induced Nephrotic Syndrome

Sign Up to like & get
recommendations! Published in 2018 at "BioMed Research International"

DOI: 10.1155/2018/3609645

Abstract: Puromycin aminonucleoside-induced nephrotic syndrome (PAN-NS) is characterized by cardiac remodeling and increased local inflammatory activity. Patients with NS and animal models of NS have vitamin D3 deficiency. The aim of the present study was to… read more here.

Keywords: puromycin aminonucleoside; aminonucleoside induced; induced nephrotic; calcitriol ... See more keywords

Renoprotective effect of topiroxostat via antioxidant activity in puromycin aminonucleoside nephrosis rats

Sign Up to like & get
recommendations! Published in 2017 at "Physiological Reports"

DOI: 10.14814/phy2.13358

Abstract: Topiroxostat is a novel inhibitor of xanthine oxidase, and is postulated to exert a renoprotective effect. Puromycin aminonucleoside nephrosis (PAN) is a rat model of minimal change nephrotic syndrome. In this study, we examined whether… read more here.

Keywords: puromycin aminonucleoside; aminonucleoside nephrosis; pan rats; topiroxostat ... See more keywords
Photo by hbsun2013 from unsplash

TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models

Sign Up to like & get
recommendations! Published in 2021 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2021.721865

Abstract: Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of kidney disease, but… read more here.

Keywords: puromycin aminonucleoside; protects podocytes; trpc5; inhibition ... See more keywords
Photo by markusspiske from unsplash

Pharmacological Melanocortin 5 Receptor Activation Attenuates Glomerular Injury and Proteinuria in Rats With Puromycin Aminonucleoside Nephrosis

Sign Up to like & get
recommendations! Published in 2022 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2022.887641

Abstract: Clinical evidence indicates that the melanocortin peptide ACTH is effective in inducing remission of nephrotic glomerulopathies like minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), including those resistant to steroids. This suggests that a… read more here.

Keywords: glomerular injury; puromycin aminonucleoside; melanocortin receptor; injury ... See more keywords
Photo from wikipedia

Decreased Excretion of Urinary Exosomal Aquaporin-2 in a Puromycin Aminonucleoside-Induced Nephrotic Syndrome Model

Sign Up to like & get
recommendations! Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21124288

Abstract: Urinary exosomes, small extracellular vesicles present in urine, are secreted from all types of renal epithelial cells. Aquaporin-2 (AQP2), a vasopressin-regulated water channel protein, is known to be selectively excreted into the urine through exosomes… read more here.

Keywords: puromycin aminonucleoside; excretion; induced nephrotic; pan ... See more keywords