PT-31, a putative α2-adrenoceptor agonist, is effective in schizophrenia cognitive symptoms in mice.
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DOI: 10.1097/fbp.0000000000000494
Abstract: Evidence of changes in central noradrenergic activity has been reported in schizophrenic patients and studies indicate that activation of the α2-adrenoceptor improves memory and neuroprotection. In this study, a new imidazolidine derivative 3-(2-chloro-6-fluorobenzyl)-imidazolidine-2,4-dione, PT-31, a… read more here.
Keywords: cognitive symptoms; memory; putative adrenoceptor; adrenoceptor ... See more keywords