Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00928-w
Abstract: Melatonin is released by the pineal gland and can modulate cardiovascular system function via the G protein-coupled melatonin receptors MT 1 and MT 2 . Most vessels are surrounded by perivascular adipose tissue (PVAT), which… read more here.
Keywords: perivascular adipose; mesenteric artery; adipose tissue; melatonin ... See more keywords
Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2015.12.056
Abstract: Background: Abdominal aortic aneurysm (AAA) is a deadly irreversible weakening and distension of the abdominal aortic wall. The pathogenesis of AAA remains poorly understood. Investigation into the physical and molecular characteristics of perivascular adipose tissue… read more here.
Keywords: perivascular adipose; tissue adjacent; adipose tissue; abdominal aortic ... See more keywords
Alogliptin improves endothelial function by promoting autophagy in perivascular adipose tissue of obese mice through a GLP-1-dependent mechanism.
Sign Up to like & getrecommendations! Published in 2019 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2018.11.003
Abstract: OBJECTIVE Perivascular adipose tissue (PVAT) regulates vascular function in a paracrine manner and the vasodilatory effect of PVAT on vessels is completely abolished in obesity. In addition, autophagy is required for maintaining biological function of… read more here.
Keywords: alogliptin; endothelial function; obese mice; function ... See more keywords
Interleukin-10 does not contribute to the anti-contractile nature of PVAT in health.
Sign Up to like & getrecommendations! Published in 2021 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2021.106838
Abstract: Perivascular adipose tissue (PVAT) is protective and reduces contraction of blood vessels in health. PVAT is composed of adipocytes, multiple types of immune cells and stromal cells. Interleukin (IL)-10, an anti-inflammatory cytokine usually produced by… read more here.
Keywords: nature pvat; contractile nature; pvat; anti contractile ... See more keywords
Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-53844-8
Abstract: Short-term preoperative methionine restriction (MetR) is a promising translatable strategy to mitigate surgical injury response. However, its application to improve post-interventional vascular remodeling remains underexplored. Here we find that MetR protects from arterial intimal hyperplasia… read more here.
Keywords: pvat; vascular remodeling; preoperative methionine; methionine restriction ... See more keywords
Endothelin-1 downregulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity.
Sign Up to like & getrecommendations! Published in 2024 at "Clinical science"
DOI: 10.1042/cs20240624
Abstract: Perivascular adipose tissue (PVAT) negatively regulates vascular muscle contraction. However, in the context of obesity, the PVAT releases vasoconstrictor substances that detrimentally affect vascular function. A pivotal player in this scenario is the peptide endothelin-1… read more here.
Keywords: pvat; obesity; dysfunction; factor ... See more keywords
Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilatation and leptin release
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvx062
Abstract: Aims Electrical field stimulation (EFS) elicits robust sensory neurogenic relaxation responses in the rat isolated mesenteric arterial bed but these responses are absent or difficult to demonstrate in isolated arteries. We believe that this mismatch… read more here.
Keywords: relaxation; pvat; leptin release; mesenteric arterial ... See more keywords
BETA3-ADRENOCEPTOR MEDIATED ADIPONECTIN SECRETION IS ESSENTIAL IN MODULATION OF VASCULAR TONE BY PERIVASCULAR ADIPOSE TISSUE
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000539033.54178.1d
Abstract: Objective: Healthy perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating blood pressure. Evidence suggests that sympathetic nervous stimulation of PVAT triggers activation of adipocyte beta3-adrenoceptors, and the subsequent release of… read more here.
Keywords: contractile effect; beta3; adiponectin; pvat ... See more keywords
Vγ6/Vδ1+ γδ T cells protect from angiotensin II effects on blood pressure and endothelial function in mice
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000003871
Abstract: Objectives: γδ T cells mediate angiotensin II (AngII)-induced hypertension and vascular injury. γδ T cells expressing specific T-cell receptor (TCR) variable (V) γ chains develop in several waves in the thymus and migrate to specific… read more here.
Keywords: function; mice; blood pressure; pvat ... See more keywords
The role of perivascular adipose tissue in obesity‐induced vascular dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13650
Abstract: Under physiological conditions, perivascular adipose tissue (PVAT) attenuates agonist‐induced vasoconstriction by releasing vasoactive molecules including hydrogen peroxide, angiotensin 1–7, adiponectin, methyl palmitate, hydrogen sulfide, NO and leptin. This anticontractile effect of PVAT is lost under… read more here.
Keywords: dysfunction; perivascular adipose; obesity induced; adipose tissue ... See more keywords
New actions of an old friend: perivascular adipose tissue's adrenergic mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13663
Abstract: The revolutionary discovery in 1991 by Soltis and Cassis that perivascular adipose tissue (PVAT) has an anti‐contractile effect changed how we think about the vasculature. Most experiments on vascular pharmacology begin by removing the fat… read more here.
Keywords: system; perivascular adipose; pharmacology; adipose tissue ... See more keywords