Production of recombinant PvDBPII, receptor binding domain of Plasmodium vivax Duffy binding protein, and evaluation of immunogenicity to identify an adjuvant formulation for vaccine development.
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DOI: 10.1016/j.pep.2015.06.011
Abstract: Plasmodium vivax is dependent on interaction with the Duffy antigen receptor for chemokines (DARC) for invasion of human erythrocytes. The P. vivax Duffy binding protein (PvDBP) mediates interaction of P. vivax merozoites with DARC. The DARC receptor-binding… read more here.
Keywords: recombinant pvdbpii; vaccine; pvdbpii; vivax ... See more keywords
PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial
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DOI: 10.1038/s41541-023-00796-7
Abstract: The receptor-binding domain, region II, of the Plasmodium vivax Duffy binding protein (PvDBPII) binds the Duffy antigen on the reticulocyte surface to mediate invasion. A heterologous vaccine challenge trial recently showed that a delayed dosing… read more here.
Keywords: vivax; antibody; challenge trial; pvdbpii ... See more keywords