The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer
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DOI: 10.1098/rsob.200109
Abstract: The von Hippel–Lindau protein (pVHL) is a tumour suppressor mainly known for its role as master regulator of hypoxia-inducible factor (HIF) activity. Functional inactivation of pVHL is causative of the von Hippel–Lindau disease, an inherited… read more here.
Keywords: pvhl; dependent independent; neglected functions; pvhl neglected ... See more keywords
The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation
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DOI: 10.1371/journal.pgen.1009183
Abstract: Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Here, we have… read more here.
Keywords: protein; pvhl; prefoldin complex; hippel lindau ... See more keywords