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   Articles with "pvhl" as a keyword



Protein kinase C iota (PKCι) and pVHL are both needed for lysosomal degradation of α5 integrin in renal carcinoma cells

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recommendations! Published in 2025 at "Molecular Biology Reports"

DOI: 10.1007/s11033-025-10272-1

Abstract: von Hippel-Lindau (VHL) hereditary cancer syndrome is caused by mutations in the VHL tumor suppressor gene and is characterized by a predisposition to form various types of tumors, including renal cell carcinomas, hemangioblastomas, and pheochromocytomas.… read more here.

Keywords: protein kinase; degradation; renal carcinoma; pkc ... See more keywords
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The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer

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recommendations! Published in 2020 at "Open Biology"

DOI: 10.1098/rsob.200109

Abstract: The von Hippel–Lindau protein (pVHL) is a tumour suppressor mainly known for its role as master regulator of hypoxia-inducible factor (HIF) activity. Functional inactivation of pVHL is causative of the von Hippel–Lindau disease, an inherited… read more here.

Keywords: pvhl; dependent independent; neglected functions; pvhl neglected ... See more keywords

UFMylation maintains tumor suppressor pVHL stability by activating the deubiquitinase BAP1

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recommendations! Published in 2025 at "Science Advances"

DOI: 10.1126/sciadv.adt8800

Abstract: BRCA1-associated protein 1 (BAP1) can function as a tumor suppressor or oncogene depending on context, but its role in colorectal cancer (CRC) is not well understood. Here, we demonstrate that BAP1 suppresses CRC progression primarily… read more here.

Keywords: bap1; ufmylation; tumor suppressor; tumor ... See more keywords

The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation

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recommendations! Published in 2020 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1009183

Abstract: Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Here, we have… read more here.

Keywords: protein; pvhl; prefoldin complex; hippel lindau ... See more keywords