4-parvifuran inhibits metastatic and invasive actions through the JAK2/STAT3 pathway in osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-017-0911-4
Abstract: This study was performed to examine the anticancer and anti-metastatic effects of 4-parvifuran (PVN), a novel flavonoid isolated from the heartwood of Dalbergia odorifera, and to study its underlying signaling pathway in human osteosarcoma cells.… read more here.
Keywords: jak2 stat3; osteosarcoma; study; pvn ... See more keywords
Functions of AT1 and AT2 angiotensin receptors in the paraventricular nucleus of the rat, correlating single-unit and cardiovascular responses
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2017.06.003
Abstract: The paraventricular hypothalamic nucleus (PVN) is a complex structure with both neuroendocrine and autonomic functions including cardiovascular control. The PVN contains angiotensin II (AngII) immunoreactive cells, fibers, as well as AT1 and AT2 receptors of… read more here.
Keywords: response; at2 receptors; single unit; pvn ... See more keywords
Activation of the hypothalamic paraventricular nucleus by acute intermittent hypoxia: Implications for sympathetic long-term facilitation neuroplasticity
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.12.011
Abstract: &NA; Exposure to acute intermittent hypoxia (AIH) induces a progressive increase of sympathetic nerve activity (SNA) that reflects a form of neuroplasticity known as sympathetic long‐term facilitation (sLTF). Our recent findings indicate that activity of… read more here.
Keywords: aih induced; long term; pvn; neuroplasticity ... See more keywords
Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.11.010
Abstract: &NA; Hypertension is associated with increased reactive oxygen species (ROS) production in the paraventricular nucleus (PVN) of the hypothalamus. Oleuropein (OL) has a variety of biochemical roles, including antihypertensive and antioxidative functions. However, there have… read more here.
Keywords: spontaneously hypertensive; hypertensive rats; paraventricular nucleus; pvn ... See more keywords
Blockade of Microglial Activation in Hypothalamic Paraventricular Nucleus Improves High-salt Induced Hypertension.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of hypertension"
DOI: 10.1093/ajh/hpac052
Abstract: BACKGROUND It has been shown that activated microglia in brain releasing proinflammatory cytokines (PICs) contribute to the progression of cardiovascular diseases. In this study, we tested the hypothesis that microglial activation in paraventricular nucleus of… read more here.
Keywords: hypertension; microglial activation; high salt; pvn ... See more keywords
Hypothalamic paraventricular nucleus hydrogen sulfide exerts antihypertensive effects in spontaneously hypertensive rats via the Nrf2 pathway.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of hypertension"
DOI: 10.1093/ajh/hpad012
Abstract: BACKGROUND Hydrogen sulfide (H2S) is widely distributed throughout the nervous system with various antioxidant and anti-inflammatory properties. Hypertension involves an increase in reactive oxygen species (ROS) and inflammation in the hypothalamic paraventricular nucleus (PVN). However,… read more here.
Keywords: paraventricular nucleus; hypothalamic paraventricular; pvn; hydrogen sulfide ... See more keywords
Adrenomedullin in paraventricular nucleus attenuates adipose afferent reflex and sympathoexcitation via receptors mediated nitric oxide–gamma-aminobutyric acid A type receptor pathway in rats with obesity-related hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000003301
Abstract: Background: Hypothalamic paraventricular nucleus (PVN) is an important central site for the control of the adipose afferent reflex (AAR) that increases sympathetic outflow and blood pressure in obesity-related hypertension (OH). Method: In this study, we… read more here.
Keywords: afferent reflex; adipose afferent; hypertension; paraventricular nucleus ... See more keywords
Endogenous oxytocin inhibits hypothalamic corticotrophin‐releasing hormone neurones following acute hypernatraemia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12839
Abstract: Significant prior evidence indicates that centrally acting oxytocin robustly modulates stress responsiveness and anxiety‐like behaviour, although the neural mechanisms behind these effects are not entirely understood. A plausible neural basis for oxytocin‐mediated stress reduction is… read more here.
Keywords: crh neurones; releasing hormone; pvn; crh ... See more keywords
The role of short-chain fatty acid receptors in the hypothalamic paraventricular nucleus of adult offspring in hypertension programmed by maternal high fructose diet exposure
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731978
Abstract: The role of short-chain fatty acids (SCFAs) in the brain on developmental programming of hypertension is poorly understood. The present study aimed to explore the dysregulated tissue levels of SCFAs and expression of SCFA-sensing receptors… read more here.
Keywords: hfd; adult; hypertension; scfa sensing ... See more keywords
Optogenetic Activation of PVN-projecting MnPO Neurons Induces Changes in Type I PVN Neurons
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731990
Abstract: The paraventricular nucleus of the hypothalamus (PVN) is an important autonomic control center that receives afferent inputs from the median preoptic nucleus (MnPO). The link between the MnPO and the PVN is essential in generating… read more here.
Keywords: mnpo; pvn neurons; type pvn; physiology ... See more keywords
Abstract 085: Loss of Microglia Enhances Neuronal Activity in the Sympathetic Paraventricular Nucleus
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.085
Abstract: Microglia, the primary immune cells in the CNS, are critical in the maintenance of brain homeostasis such as participating neurogenesis and pruning synapses. Our previous work indicates that microglia are activated in hypertension; depletion of… read more here.
Keywords: neuronal activity; microglia; loss microglia; pvn ... See more keywords