Effect of variability of physical properties of povidone K30 on crystallization and drug-polymer miscibility of celecoxib-povidone K30 amorphous solid dispersion.
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DOI: 10.1021/acs.molpharmaceut.9b00452
Abstract: In the present study, we have investigated the variability in physical properties of povidone K30 (PVP K30) and its impact on crystallization and drug-polymer miscibility of celecoxib-PVP K30 (CLB-PVP K30) amorphous solid dispersions (ASDs). CLB-PVP… read more here.
Keywords: drug polymer; crystallization; polymer miscibility; miscibility ... See more keywords
The Opposed Effects of Polyvinylpyrrolidone K30 on Dissolution and Precipitation for Indomethacin Supersaturating Drug Delivery Systems
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DOI: 10.1208/s12249-020-01647-7
Abstract: Amorphous solid dispersions (ASD) are one of the most important supersaturating drug delivery systems (SDDS) for poorly water-soluble drugs to improve their bioavailability. As a result of thermodynamic instability, drug molecules tend to precipitate during… read more here.
Keywords: drug; dissolution; pvp k30; precipitation ... See more keywords
Preparation and Characterization of Furosemide Solid Dispersion with Enhanced Solubility and Bioavailability
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DOI: 10.1208/s12249-022-02208-w
Abstract: Furosemide (FMD), as a potent circulating diuretic, is commonly used for the treatment of hypertension and edema arising from cardiac, renal, and hepatic failure. However, the low solubility of furosemide restricts its dissolution and bioavailability.… read more here.
Keywords: furosemide; solubility; pvp k30; solid dispersion ... See more keywords
Enhancing Intradermal Delivery of Lidocaine by Dissolving Microneedles: Comparison between Hyaluronic Acid and Poly(Vinyl Pyrrolidone) Backbone Polymers
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DOI: 10.3390/pharmaceutics15010289
Abstract: Lidocaine hydrochloride (LiH), an amide-type local anesthetic agent, is commonly used in dermatological procedures. LiH is categorized as a BCS (biopharmaceutics classification system) class III group, which has high solubility and poor permeability. It should… read more here.
Keywords: pvp k30; poly vinyl; vinyl pyrrolidone; hyaluronic acid ... See more keywords