Serum lncRNA PVT1 and Its Targets miR-146a and SIRT1 as Biomarkers for the Early Detection of Breast Cancer and Its Metastasis.
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DOI: 10.1002/bab.2769
Abstract: Early detection of breast cancer (BC) and its metastasis greatly improves the patients’ outcomes. The long noncoding RNA plasmacytoma variant translocation 1 (PVT1) and its targets, microRNA‐146a and sirtuin 1 (SIRT1), affect BC development; however,… read more here.
Keywords: pvt1; early detection; pvt1 mir; mir 146a ... See more keywords
Aberrant expression of long non‐coding RNA PVT1 in allergic rhinitis children: Correlation with disease risk, symptoms, and Th1/Th2 imbalance
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DOI: 10.1002/jcla.24281
Abstract: Long non‐coding RNA plasmacytoma variant translocation 1 (lnc‐PVT1) exacerbates inflammation and induces T helper (Th) 1/Th2 imbalance in allergic diseases, but its clinical role in allergic rhinitis (AR) remains unclear. Hence, we conducted this study… read more here.
Keywords: long non; th2 imbalance; allergic rhinitis; pvt1 ... See more keywords
Analysis of anti‐apoptotic PVT1 oncogene and apoptosis‐related proteins (p53, Bcl2, PD‐1, and PD‐L1) expression in thyroid carcinoma
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DOI: 10.1002/jcla.24390
Abstract: An aberrant expression of long non‐coding RNA PVT1 has been associated with apoptosis in various cancer types. We aimed to explore the PVT1 and four apoptosis‐related proteins (p53, Bcl2, and PD‐1/PD‐L1) signature in thyroid cancer… read more here.
Keywords: p53 bcl2; related proteins; proteins p53; expression ... See more keywords
Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway
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DOI: 10.1002/jcp.28264
Abstract: The aim of this study is to investigate the effects of long‐chain noncoding RNA plasmacytoma variant translocation 1 (PVT1) on the activation of astrocytes and the expression of brain‐derived neurotrophic factor (BDNF) in hippocampus tissues… read more here.
Keywords: activation astrocytes; hippocampus; pvt1; expression ... See more keywords
lncRNA PVT1 promotes the migration of gastric cancer by functioning as ceRNA of miR‐30a and regulating Snail
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DOI: 10.1002/jcp.29881
Abstract: Although the incidence and mortality of gastric cancer (GC) are slowly decreasing, the overall prognosis of GC patients with distal metastasis remains dismal. Long non‐coding RNA PVT1 has been verified to function as a tumor… read more here.
Keywords: gastric cancer; pvt1; metastasis; snail ... See more keywords
Hypermethylation‐mediated downregulation of lncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a
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DOI: 10.1002/jcp.30222
Abstract: Long noncoding RNA PVT1 is involved in the progression of female gynecological cancers. However, the role of PVT1 in ovarian granulosa cell apoptosis‐mediated premature ovarian insufficiency (POI) remains unclear. This study aims to elucidate the… read more here.
Keywords: granulosa cell; cell apoptosis; pvt1;
Long noncoding RNA PVT1 accelerates the growth of placental trophoblasts in preeclampsia through the microRNA‐24‐3p/HSD11B2 axis
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DOI: 10.1002/mrd.23575
Abstract: Long noncoding RNA plasmacytoma variant translocation 1 (PVT1) is essential for the maintenance of normal functions of trophoblasts in preeclampsia (PE). This study aims to decipher the concrete mechanism of PVT1 with the microRNA‐24‐3p/Type‐2 11β‐hydroxysteroid… read more here.
Keywords: hsd11b2; htr svneo; growth; pvt1 ... See more keywords
Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis
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DOI: 10.1007/s00018-019-03222-1
Abstract: Numerous studies have shown that non-coding RNAs play crucial roles in the development and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly encodes a long non-coding RNA (lncRNA) and is located on… read more here.
Keywords: pvt1; long non; non coding; coding rna ... See more keywords
LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF-β/SMAD4 signaling
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DOI: 10.1007/s00774-020-01199-7
Abstract: To investigate the role of LncRNA PVT1 (plasmacytoma variant translocation 1) in hyperglycemia-triggered cartilage damage using the diabetic osteoarthritis (OA) mice model. Streptozotocin (STZ) was used to induce mouse diabetes. Knee OA model was induced… read more here.
Keywords: mir 146a; pvt1; tgf smad4; mice ... See more keywords
LncRNA PVT1 accelerates LPS-induced septic acute kidney injury through targeting miR-17-5p and regulating NF-κB pathway
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DOI: 10.1007/s11255-021-02905-8
Abstract: Long noncoding RNA PVT1 is associated with diverse human diseases, including acute kidney injury (AKI). However, our understandings of PVT1 on septic AKI are limited. The septic AKI model was constructed through lipopolysaccharide (LPS) treatment.… read more here.
Keywords: mir; acute kidney; pvt1; kidney injury ... See more keywords
M1 Macrophage-Derived Exosome LncRNA PVT1 Promotes Inflammation and Pyroptosis of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm by Inhibiting miR-186-5p and Regulating HMGB1
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DOI: 10.1007/s12012-024-09838-5
Abstract: Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease. Vascular smooth muscle cells (VSMCs) are essential for maintaining the integrity of healthy blood vessels. Macrophages play an important role in the inflammatory process of… read more here.
Keywords: pvt1; pyroptosis; mir 186; hmgb1 ... See more keywords