BRAF V600E, TERT, and IDH2 Mutations in Pleomorphic Xanthoastrocytoma: Observations from a Large Case-Series Study.
Sign Up to like & getrecommendations! Published in 2018 at "World neurosurgery"
DOI: 10.1016/j.wneu.2018.09.050
Abstract: BACKGROUND Anaplastic pleomorphic xanthoastrocytoma (PXA) was added to grade III glial tumors as a distinct entity in the 2016 World Health Organization (WHO) classification of tumors of the central nervous system. We retrospectively reviewed and… read more here.
Keywords: braf v600e; v600e tert; pleomorphic xanthoastrocytoma; pxa ... See more keywords
Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac044
Abstract: Composite pleomorphic xanthoastrocytoma-ganglioglioma (PXA-GG) is an extremely rare central nervous system neoplasm with 2 distinct but intermingled components. Whether this tumor represents a "collision tumor" of separate neoplasms or a monoclonal neoplasm with divergent evolution… read more here.
Keywords: pxa; xanthoastrocytoma ganglioglioma; pxa components; pleomorphic xanthoastrocytoma ... See more keywords
RARE-18. CLINICAL EXPERIENCE OF DABRAFENIB IN COMBINATION WITH TRAMETINIB TREATMENT FOR ANAPLASTIC PXA CASES
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.941
Abstract: Anaplastic PXA is classed as grade III tumor because of its aggressive behavior in 2016 WHO classification. Typical treatment of PXA is gross total resection followed by radiotherapy and cytotoxic chemotherapy at recurrence. Despite aggressive… read more here.
Keywords: anaplastic pxa; treatment; braf v600; pxa ... See more keywords
Recurrent copy number alterations in low‐grade and anaplastic pleomorphic xanthoastrocytoma with and without BRAF V600E mutation
Sign Up to like & getrecommendations! Published in 2018 at "Brain Pathology"
DOI: 10.1111/bpa.12495
Abstract: Pleomorphic xanthoastrocytoma (PXA) is a rare localized glioma characterized by frequent BRAF V600E mutation and CDKN2A/B deletion. We explored the association of copy‐number variants (CNVs) with BRAF mutations, tumor grade, and patient survival in a… read more here.
Keywords: braf v600e; pxa; copy number;
Suprasellar pleomorphic xanthoastrocytoma: A case report
Sign Up to like & getrecommendations! Published in 2019 at "Surgical Neurology International"
DOI: 10.25259/sni-83-2019
Abstract: Background: Pleomorphic xanthoastrocytoma (PXA) is a rare form of astrocytic neoplasm most commonly found in children and young adults. This neoplasm, which is classified as a Grade II tumor by the World Health Organization classification… read more here.
Keywords: pleomorphic xanthoastrocytoma; pxa; region; case ... See more keywords
Clinical, Morphological, and Molecular Study on Grade 2 and 3 Pleomorphic Xanthoastrocytoma
Sign Up to like & getrecommendations! Published in 2023 at "Current Oncology"
DOI: 10.3390/curroncol30020183
Abstract: Purpose: Pleomorphic xanthoastrocytoma (PXA) is an uncommon astrocytoma that tends to occur in children and young adults and has a relatively favorable prognosis. The 2021 WHO classification of tumors of the central nervous system (CNS… read more here.
Keywords: grade pxa; pxa; clinical morphological; pleomorphic xanthoastrocytoma ... See more keywords