Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes‐Associated Protein Activation in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30131
Abstract: Activation of pregnane X receptor (PXR), a nuclear receptor that controls xenobiotic and endobiotic metabolism, is known to induce liver enlargement, but the molecular signals and cell types responding to PXR‐induced hepatomegaly remain unknown. In… read more here.
Keywords: liver; size; mice; activation ... See more keywords
Is This the Time to Reconsider the Names for Xenobiotic Nuclear Receptors?
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DOI: 10.1002/hep.30218
Abstract: Pregnane X receptor (PXR) has been known as a xenobiotic nuclear receptor and transcriptional factor that is important for inducing the expression of genes involved in drug disposition (1, 2). Recently, PXR has emerged to… read more here.
Keywords: time reconsider; nuclear receptors; names xenobiotic; xenobiotic nuclear ... See more keywords
Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21648
Abstract: Pregnane X receptor (PXR) is a ligand‐activated nuclear receptor (NR) that was originally identified as a master regulator of xenobiotic detoxification. It regulates the expression of drug‐metabolizing enzymes and transporters to control the degradation and… read more here.
Keywords: metabolism; drug; pxr; pregnane receptor ... See more keywords
Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-1948-3
Abstract: Unintentional activation of xenosensing nuclear receptors pregnane X receptor (PXR) and/or constitutive androstane receptor (CAR) by clinical drug use is known to produce severe side effects in patients, which may be overcome by co-administering antagonists.… read more here.
Keywords: pregnane receptor; dibenzazepine carbamate; pxr; receptor ... See more keywords
Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of toxicology"
DOI: 10.1007/s00204-021-03177-y
Abstract: The pregnane X receptor (PXR) is a ligand-activated nuclear receptor controlling hepatocyte expression of numerous genes. Although expression changes in xenobiotic-metabolizing, lipogenic, gluconeogenic and bile acid synthetic genes have been described after PXR activation, the… read more here.
Keywords: controlled genes; expression; pxr; receptor ... See more keywords
Variability of voriconazole concentrations in patients with hematopoietic stem cell transplantation and hematological malignancies: influence of loading dose, procalcitonin, and pregnane X receptor polymorphisms
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02831-1
Abstract: Aims Voriconazole (VCZ) displays highly variable pharmacokinetics affecting treatment efficacy and safety. We aimed to identify the factors affecting VCZ steady-state trough concentration (Cssmin) to provide evidence for optimizing VCZ treatment regimens. Methods A total… read more here.
Keywords: cssmin; hematopoietic stem; pxr; vcz ... See more keywords
Computed tomography versus plain radiography assessment of acetabular fracture reduction is more predictive for native hip survivorship
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Orthopaedic and Trauma Surgery"
DOI: 10.1007/s00402-019-03192-w
Abstract: IntroductionComputed tomography (CT) is more accurate than plain pelvic radiography (PXR) for evaluating acetabular fracture reduction. As yet unknown is whether CT-based assessment is more predictive for clinical outcome. We determined the independent association between… read more here.
Keywords: reduction; acetabular fracture; hip survivorship; hip ... See more keywords
The responses of Oncorhynchus mykiss coping with BDE-47 stress via PXR-mediated detoxification and Nrf2-mediated antioxidation system.
Sign Up to like & getrecommendations! Published in 2019 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2018.11.026
Abstract: The low brominated polybrominated diphenyl ether (PBDE) 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) is ubiquitous in the marine environment. To elucidate the stress response and possible mechanisms underlying BDE-47, the rainbow trout fish Oncorhynchus mykiss were selected and… read more here.
Keywords: bde; system; detoxification; stress ... See more keywords
Identification of novel pregnane X receptor (PXR) agonists by In silico and biological activity analyses and reversal of cigarette smoke-induced PXR downregulation.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.145
Abstract: Cigarette smoke (CS) contains many toxins that collectively harm nearly every organ in the body, and smoking is a key risk factor for many chronic diseases. Aside from its toxic actions, CS may alter expression… read more here.
Keywords: receptor pxr; cigarette smoke; pxr; pregnane receptor ... See more keywords
Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114698
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease due to the current epidemics of obesity and diabetes. The pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor known for trans-activating liver… read more here.
Keywords: obesity; inflammation; gut microbiome; liver disease ... See more keywords
CYP3A suppression during diet-induced nonalcoholic fatty liver disease is independent of PXR regulation.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.05.038
Abstract: Cytochrome P450 3A (CYP3A) activity is inhibited, and its expression is suppressed during many diseases, including nonalcoholic fatty liver disease (NAFLD). However, the mechanism is controversial. Here, we report that PXR may not take part… read more here.
Keywords: fatty liver; cyp3a; pxr; nonalcoholic fatty ... See more keywords