Response of the nuclear receptors PXR and CAR and their target gene mRNA expression in female piglets exposed to zearalenone
Sign Up to like & getrecommendations! Published in 2018 at "Toxicon"
DOI: 10.1016/j.toxicon.2018.06.081
Abstract: ABSTRACT A study was conducted to determine the effects of zearalenone (ZEN) on the mRNA expression of pregnane X receptor (PXR), constitutive and rostane receptor (CAR), and phase I and II enzymes as well as… read more here.
Keywords: nuclear receptors; pxr car; female piglets; expression ... See more keywords
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
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DOI: 10.1093/nar/gkac133
Abstract: Abstract The 48 human nuclear receptors (NRs) form a superfamily of transcription factors that regulate major physiological and pathological processes. Emerging evidence suggests that NR crosstalk can fundamentally change our understanding of NR biology, but… read more here.
Keywords: pxr car; nuclear receptors; pxr; car ... See more keywords
Xenobiotic Receptors, a Journey of Rewards
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DOI: 10.1124/dmd.122.000857
Abstract: The xenobiotic nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were discovered or characterized in 1998. PXR and CAR have since been defined as master regulators of xenobiotic responses through their transcriptional… read more here.
Keywords: pxr car; xenobiotic receptors; car; receptors journey ... See more keywords
Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond
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DOI: 10.1124/dmd.122.000858
Abstract: Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are ligand-activated transcription factors that regulate the expression of drug metabolizing enzymes and drug transporters. Since their discoveries, they have been studied as important factors for… read more here.
Keywords: car; pxr car; drug; drug metabolism ... See more keywords